Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067609789> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2067609789 endingPage "515" @default.
- W2067609789 startingPage "511" @default.
- W2067609789 abstract "Aims This study investigates whether the calcium-sensing receptor (CaR) is commonly expressed in primary breast cancers. The CaR controls secretion of PTHrP in several breast cancer cell lines and PTHrP is known to stimulate osteolysis during metastatic bone resorption. Whether this could explain the propensity of breast cancers to develop bone metastases has not been explored. Methods With Ethical Committee approval, immunohistochemistry was performed using a commercially available antiCaR antibody (AffinityBioReagents, Cambridge, UK) on archived histological sections of primary tumours from patients who died with advanced breast cancer. Intensity of CaR expression was assessed by two independent observers on a 6-point scale. Results One hundred and eight patients with breast cancer were found to have positive bone scans, 42 patients had died. Of the patients with negative bone scans, 23 had liver or lung metastases. Most patients with strongly expressed CaR (score 4–5 on immunohistochemistry) had bone metastases (13/15 patients) compared with 2/23 patients with normal bone scans (p<0.001, χ2 test). Other clinical/pathological markers (ER, PR, c-erb B-2, LN status) were not significantly different between patients with CaR-positive or CaR-negative tumours. Conclusions CaR expression is common in a selected group of patients with advanced primary breast cancers. A prospective study should investigate if patients with CaR-positive tumours are more likely to develop bone metastases." @default.
- W2067609789 created "2016-06-24" @default.
- W2067609789 creator A5007854957 @default.
- W2067609789 creator A5019865174 @default.
- W2067609789 creator A5047926650 @default.
- W2067609789 creator A5087217489 @default.
- W2067609789 date "2006-06-01" @default.
- W2067609789 modified "2023-09-28" @default.
- W2067609789 title "Expression of the calcium receptor in human breast cancer—a potential new marker predicting the risk of bone metastases" @default.
- W2067609789 cites W143805906 @default.
- W2067609789 cites W1965434694 @default.
- W2067609789 cites W2008642700 @default.
- W2067609789 cites W2008698773 @default.
- W2067609789 cites W2009441758 @default.
- W2067609789 cites W2030363901 @default.
- W2067609789 cites W2043062621 @default.
- W2067609789 cites W2047907147 @default.
- W2067609789 cites W2049907597 @default.
- W2067609789 cites W2057993678 @default.
- W2067609789 cites W2061028210 @default.
- W2067609789 cites W2098891062 @default.
- W2067609789 cites W2100197975 @default.
- W2067609789 cites W2105198696 @default.
- W2067609789 cites W2143520831 @default.
- W2067609789 cites W2157215186 @default.
- W2067609789 cites W4232701031 @default.
- W2067609789 cites W4237326861 @default.
- W2067609789 cites W4244452570 @default.
- W2067609789 cites W4252001832 @default.
- W2067609789 cites W4254079664 @default.
- W2067609789 cites W4255218637 @default.
- W2067609789 doi "https://doi.org/10.1016/j.ejso.2006.02.009" @default.
- W2067609789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16564154" @default.
- W2067609789 hasPublicationYear "2006" @default.
- W2067609789 type Work @default.
- W2067609789 sameAs 2067609789 @default.
- W2067609789 citedByCount "102" @default.
- W2067609789 countsByYear W20676097892012 @default.
- W2067609789 countsByYear W20676097892013 @default.
- W2067609789 countsByYear W20676097892014 @default.
- W2067609789 countsByYear W20676097892015 @default.
- W2067609789 countsByYear W20676097892016 @default.
- W2067609789 countsByYear W20676097892017 @default.
- W2067609789 countsByYear W20676097892018 @default.
- W2067609789 countsByYear W20676097892019 @default.
- W2067609789 countsByYear W20676097892020 @default.
- W2067609789 countsByYear W20676097892021 @default.
- W2067609789 countsByYear W20676097892022 @default.
- W2067609789 countsByYear W20676097892023 @default.
- W2067609789 crossrefType "journal-article" @default.
- W2067609789 hasAuthorship W2067609789A5007854957 @default.
- W2067609789 hasAuthorship W2067609789A5019865174 @default.
- W2067609789 hasAuthorship W2067609789A5047926650 @default.
- W2067609789 hasAuthorship W2067609789A5087217489 @default.
- W2067609789 hasConcept C121608353 @default.
- W2067609789 hasConcept C126322002 @default.
- W2067609789 hasConcept C126838900 @default.
- W2067609789 hasConcept C142724271 @default.
- W2067609789 hasConcept C143998085 @default.
- W2067609789 hasConcept C204232928 @default.
- W2067609789 hasConcept C207886595 @default.
- W2067609789 hasConcept C2781282405 @default.
- W2067609789 hasConcept C530470458 @default.
- W2067609789 hasConcept C673006 @default.
- W2067609789 hasConcept C71924100 @default.
- W2067609789 hasConceptScore W2067609789C121608353 @default.
- W2067609789 hasConceptScore W2067609789C126322002 @default.
- W2067609789 hasConceptScore W2067609789C126838900 @default.
- W2067609789 hasConceptScore W2067609789C142724271 @default.
- W2067609789 hasConceptScore W2067609789C143998085 @default.
- W2067609789 hasConceptScore W2067609789C204232928 @default.
- W2067609789 hasConceptScore W2067609789C207886595 @default.
- W2067609789 hasConceptScore W2067609789C2781282405 @default.
- W2067609789 hasConceptScore W2067609789C530470458 @default.
- W2067609789 hasConceptScore W2067609789C673006 @default.
- W2067609789 hasConceptScore W2067609789C71924100 @default.
- W2067609789 hasIssue "5" @default.
- W2067609789 hasLocation W20676097891 @default.
- W2067609789 hasLocation W20676097892 @default.
- W2067609789 hasOpenAccess W2067609789 @default.
- W2067609789 hasPrimaryLocation W20676097891 @default.
- W2067609789 hasRelatedWork W2074513640 @default.
- W2067609789 hasRelatedWork W2347956231 @default.
- W2067609789 hasRelatedWork W2360428741 @default.
- W2067609789 hasRelatedWork W2362074479 @default.
- W2067609789 hasRelatedWork W2366827179 @default.
- W2067609789 hasRelatedWork W2368973816 @default.
- W2067609789 hasRelatedWork W2377185737 @default.
- W2067609789 hasRelatedWork W2463033561 @default.
- W2067609789 hasRelatedWork W3029310622 @default.
- W2067609789 hasRelatedWork W377899687 @default.
- W2067609789 hasVolume "32" @default.
- W2067609789 isParatext "false" @default.
- W2067609789 isRetracted "false" @default.
- W2067609789 magId "2067609789" @default.
- W2067609789 workType "article" @default.