FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067612902> ?p ?o ?g. }

• W2067612902 endingPage "599" @default.
• W2067612902 startingPage "589" @default.
• W2067612902 abstract "Mutations of αB-crystallin (CryαB), a small heat shock protein abundantly expressed in cardiac and skeletal muscles, are known to cause desmin-related myopathies. The CryαB R120G allele has been linked to a familial desminopathy and, in transgenic mice, causes a sudden death at about 28 weeks of age. To investigate the mechanisms of the sudden cardiac arrest of CryαB R120G transgenic mice, we prepared protein samples from left ventricular tissues of two different age groups (10 and 28 weeks) and examined Ca(2+) -handling proteins. Expression of sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) 2, phospholamban, ryanodine receptor 2 and calsequestrin 2 was significantly decreased in 28- versus 10-week-old CryαB R120G transgenic mice. In addition, low heart rate variability, including heart rate, total power and low frequency, was observed and continuous electrocardiogram monitoring revealed cardiac arrhythmias, such as ventricular tachycardia, atrioventricular block and atrial flutter, in 28-week-old CryαB R120G transgenic mice. In contrast, expression of endoplasmic reticulum (ER) degradation enhancing α-mannosidase-like protein, inositol requirement 1 and X-box binding protein 1 were increased significantly in 28- versus 10-week-old CryαBR120G transgenic mice, suggesting that the CryαBR120G transgenic mice exhibit increased ER stress compared with wild-type mice. Together, the data suggest that the CryαB R120G dominant variant induces ER stress and impairs Ca(2+) regulation, leading to ageing-related cardiac dysfunction, arrhythmias and decreased autonomic tone with shortened lifespan." @default.
• W2067612902 created "2016-06-24" @default.
• W2067612902 creator A5004719355 @default.
• W2067612902 creator A5045996504 @default.
• W2067612902 creator A5065491742 @default.
• W2067612902 creator A5066286401 @default.
• W2067612902 creator A5086057238 @default.
• W2067612902 date "2014-08-01" @default.
• W2067612902 modified "2023-10-06" @default.
• W2067612902 title "<i>α</i>B-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca²⁺-handling proteins and endoplasmic reticulum stress in mice" @default.
• W2067612902 cites W1604252033 @default.
• W2067612902 cites W168707126 @default.
• W2067612902 cites W1765185969 @default.
• W2067612902 cites W1822372593 @default.
• W2067612902 cites W1979104457 @default.
• W2067612902 cites W1980852443 @default.
• W2067612902 cites W1984943566 @default.
• W2067612902 cites W1985124530 @default.
• W2067612902 cites W1993318724 @default.
• W2067612902 cites W1998179950 @default.
• W2067612902 cites W2007496244 @default.
• W2067612902 cites W2013437088 @default.
• W2067612902 cites W2029139076 @default.
• W2067612902 cites W2029633430 @default.
• W2067612902 cites W2029666407 @default.
• W2067612902 cites W2034579187 @default.
• W2067612902 cites W2036920310 @default.
• W2067612902 cites W2040664931 @default.
• W2067612902 cites W2040826404 @default.
• W2067612902 cites W2045351586 @default.
• W2067612902 cites W2048559246 @default.
• W2067612902 cites W2050423231 @default.
• W2067612902 cites W2052396447 @default.
• W2067612902 cites W2060374317 @default.
• W2067612902 cites W2069866232 @default.
• W2067612902 cites W2071102501 @default.
• W2067612902 cites W2083442921 @default.
• W2067612902 cites W2084737793 @default.
• W2067612902 cites W2093114736 @default.
• W2067612902 cites W2100603377 @default.
• W2067612902 cites W2110059166 @default.
• W2067612902 cites W2111449138 @default.
• W2067612902 cites W2112428065 @default.
• W2067612902 cites W2112649634 @default.
• W2067612902 cites W2127812911 @default.
• W2067612902 cites W2130466887 @default.
• W2067612902 cites W2131653261 @default.
• W2067612902 cites W2133277482 @default.
• W2067612902 cites W2136811516 @default.
• W2067612902 cites W2140608810 @default.
• W2067612902 cites W2152513067 @default.
• W2067612902 cites W2152957270 @default.
• W2067612902 cites W2158976222 @default.
• W2067612902 cites W2163318181 @default.
• W2067612902 cites W2165216108 @default.
• W2067612902 cites W2166500974 @default.
• W2067612902 cites W2171288127 @default.
• W2067612902 doi "https://doi.org/10.1111/1440-1681.12253" @default.
• W2067612902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24825000" @default.
• W2067612902 hasPublicationYear "2014" @default.
• W2067612902 type Work @default.
• W2067612902 sameAs 2067612902 @default.
• W2067612902 citedByCount "19" @default.
• W2067612902 countsByYear W20676129022014 @default.
• W2067612902 countsByYear W20676129022015 @default.
• W2067612902 countsByYear W20676129022016 @default.
• W2067612902 countsByYear W20676129022017 @default.
• W2067612902 countsByYear W20676129022018 @default.
• W2067612902 countsByYear W20676129022019 @default.
• W2067612902 countsByYear W20676129022020 @default.
• W2067612902 countsByYear W20676129022022 @default.
• W2067612902 countsByYear W20676129022023 @default.
• W2067612902 crossrefType "journal-article" @default.
• W2067612902 hasAuthorship W2067612902A5004719355 @default.
• W2067612902 hasAuthorship W2067612902A5045996504 @default.
• W2067612902 hasAuthorship W2067612902A5065491742 @default.
• W2067612902 hasAuthorship W2067612902A5066286401 @default.
• W2067612902 hasAuthorship W2067612902A5086057238 @default.
• W2067612902 hasConcept C102230213 @default.
• W2067612902 hasConcept C104317684 @default.
• W2067612902 hasConcept C113217602 @default.
• W2067612902 hasConcept C126322002 @default.
• W2067612902 hasConcept C134018914 @default.
• W2067612902 hasConcept C139447449 @default.
• W2067612902 hasConcept C141035611 @default.
• W2067612902 hasConcept C158617107 @default.
• W2067612902 hasConcept C17137333 @default.
• W2067612902 hasConcept C181199279 @default.
• W2067612902 hasConcept C185592680 @default.
• W2067612902 hasConcept C190712762 @default.
• W2067612902 hasConcept C23265538 @default.
• W2067612902 hasConcept C2775953344 @default.
• W2067612902 hasConcept C2781414619 @default.
• W2067612902 hasConcept C55493867 @default.
• W2067612902 hasConcept C71924100 @default.
• W2067612902 hasConcept C86803240 @default.
• W2067612902 hasConcept C95444343 @default.
• W2067612902 hasConceptScore W2067612902C102230213 @default.

• next