FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067625960> ?p ?o ?g. }

• W2067625960 endingPage "250" @default.
• W2067625960 startingPage "237" @default.
• W2067625960 abstract "Time-resolved fluorescence techniques have been employed to compare the DNA association constant of the parent hydrocarbon benzo[a]pyrene versus that of trans-7, 8-dihydroxy-7, 8-dihydrobenzo[a]pyrene. The latter molecule is a highly carcinogenic metabolite derived from benzo[a]pyrene. Solubilization experiments were also carried out to compare the maximum total uptake of benzo[a]pyrene and of the metabolite by DNA. In the solvent system used in the association constant measurements (20% methanol) the association constant for benzo[a]pyrene is 3.0+0.3 × 104 M-1 while that of the more polar proximate carcinogen is 7.5 times lower. The results of the solubilization studies carried out in buffered aqueous medium demonstrate that at a DNA concentration of 5 × 10-4 M in PO-4 the maximum uptake of benzo[a]pyrene into DNA is one molecule per 2.2+0.5 × 103 nucleotide bases. The maximum uptake of the more soluble proximate carcinogen is 4 to 25 times greater than that of the parent hydrocarbon. The present results indicate that metabolism of benzo[a]pyrene leads to the formation of a nonreactive proximate carcinogen which has a lower binding constant than the parent hydrocarbon, but which is better able to diffuse through a polar medium and to accumulate at ultimate biological target sites." @default.
• W2067625960 created "2016-06-24" @default.
• W2067625960 creator A5007837500 @default.
• W2067625960 creator A5010351015 @default.
• W2067625960 creator A5011151564 @default.
• W2067625960 creator A5025994630 @default.
• W2067625960 date "2009-06-19" @default.
• W2067625960 modified "2023-09-26" @default.
• W2067625960 title "Time-resolved fluorescence studies of the effects of metabolism on the In Vitro reversible binding and accumulation of benzo[a]pyrene in DNA" @default.
• W2067625960 cites W1974648730 @default.
• W2067625960 cites W1975633800 @default.
• W2067625960 cites W1975922606 @default.
• W2067625960 cites W2000383298 @default.
• W2067625960 cites W2006622543 @default.
• W2067625960 cites W2008291644 @default.
• W2067625960 cites W2024512007 @default.
• W2067625960 cites W2025672003 @default.
• W2067625960 cites W2033143526 @default.
• W2067625960 cites W2034775013 @default.
• W2067625960 cites W2038457576 @default.
• W2067625960 cites W2043645846 @default.
• W2067625960 cites W2049495053 @default.
• W2067625960 cites W2058468335 @default.
• W2067625960 cites W2062093570 @default.
• W2067625960 cites W2066867653 @default.
• W2067625960 cites W2075986780 @default.
• W2067625960 cites W2079719114 @default.
• W2067625960 cites W2081111771 @default.
• W2067625960 cites W2091003207 @default.
• W2067625960 cites W2107753038 @default.
• W2067625960 cites W2493444807 @default.
• W2067625960 cites W2501820592 @default.
• W2067625960 cites W3005117706 @default.
• W2067625960 cites W4236529637 @default.
• W2067625960 cites W62903774 @default.
• W2067625960 doi "https://doi.org/10.1002/qua.560300823" @default.
• W2067625960 hasPublicationYear "2009" @default.
• W2067625960 type Work @default.
• W2067625960 sameAs 2067625960 @default.
• W2067625960 citedByCount "0" @default.
• W2067625960 crossrefType "journal-article" @default.
• W2067625960 hasAuthorship W2067625960A5007837500 @default.
• W2067625960 hasAuthorship W2067625960A5010351015 @default.
• W2067625960 hasAuthorship W2067625960A5011151564 @default.
• W2067625960 hasAuthorship W2067625960A5025994630 @default.
• W2067625960 hasConcept C114246631 @default.
• W2067625960 hasConcept C121332964 @default.
• W2067625960 hasConcept C178790620 @default.
• W2067625960 hasConcept C185592680 @default.
• W2067625960 hasConcept C2777207669 @default.
• W2067625960 hasConcept C2777477808 @default.
• W2067625960 hasConcept C2777538855 @default.
• W2067625960 hasConcept C2778951431 @default.
• W2067625960 hasConcept C2779033964 @default.
• W2067625960 hasConcept C552990157 @default.
• W2067625960 hasConcept C55493867 @default.
• W2067625960 hasConcept C62231903 @default.
• W2067625960 hasConcept C62520636 @default.
• W2067625960 hasConcept C71240020 @default.
• W2067625960 hasConcept C75473681 @default.
• W2067625960 hasConcept C91881484 @default.
• W2067625960 hasConceptScore W2067625960C114246631 @default.
• W2067625960 hasConceptScore W2067625960C121332964 @default.
• W2067625960 hasConceptScore W2067625960C178790620 @default.
• W2067625960 hasConceptScore W2067625960C185592680 @default.
• W2067625960 hasConceptScore W2067625960C2777207669 @default.
• W2067625960 hasConceptScore W2067625960C2777477808 @default.
• W2067625960 hasConceptScore W2067625960C2777538855 @default.
• W2067625960 hasConceptScore W2067625960C2778951431 @default.
• W2067625960 hasConceptScore W2067625960C2779033964 @default.
• W2067625960 hasConceptScore W2067625960C552990157 @default.
• W2067625960 hasConceptScore W2067625960C55493867 @default.
• W2067625960 hasConceptScore W2067625960C62231903 @default.
• W2067625960 hasConceptScore W2067625960C62520636 @default.
• W2067625960 hasConceptScore W2067625960C71240020 @default.
• W2067625960 hasConceptScore W2067625960C75473681 @default.
• W2067625960 hasConceptScore W2067625960C91881484 @default.
• W2067625960 hasIssue "S13" @default.
• W2067625960 hasLocation W20676259601 @default.
• W2067625960 hasOpenAccess W2067625960 @default.
• W2067625960 hasPrimaryLocation W20676259601 @default.
• W2067625960 hasRelatedWork W1557212153 @default.
• W2067625960 hasRelatedWork W1606916058 @default.
• W2067625960 hasRelatedWork W1769273632 @default.
• W2067625960 hasRelatedWork W1970252759 @default.
• W2067625960 hasRelatedWork W1970608057 @default.
• W2067625960 hasRelatedWork W1983011853 @default.
• W2067625960 hasRelatedWork W198497531 @default.
• W2067625960 hasRelatedWork W2005607271 @default.
• W2067625960 hasRelatedWork W2024236499 @default.
• W2067625960 hasRelatedWork W2032777947 @default.
• W2067625960 hasRelatedWork W2064449868 @default.
• W2067625960 hasRelatedWork W2070788829 @default.
• W2067625960 hasRelatedWork W2084761697 @default.
• W2067625960 hasRelatedWork W2089000160 @default.
• W2067625960 hasRelatedWork W2093684972 @default.
• W2067625960 hasRelatedWork W2110691834 @default.
• W2067625960 hasRelatedWork W2332199712 @default.

• next