Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067633335> ?p ?o ?g. }
- W2067633335 endingPage "169" @default.
- W2067633335 startingPage "164" @default.
- W2067633335 abstract "Cancer metastasis is a complex multi-step process, responsible for a majority of cancer-related deaths by affecting the critical organs and causing complications in therapies. Hepatocellular carcinoma is a multi-factorial disease and is the third most common cause of cancer related mortality worldwide. Clinical and experimental studies have shown that MMP-2 and MMP-9 are involved in tumor invasion and metastases and their elevated expression has been associated with poor prognosis. Our recent studies showed a strong anti-oxidant and hepatoprotective effects of bacoside A (BA) against carcinogen. Nevertheless the effect of BA on the activities and expression of MMP-2 and MMP-9 during hepatocellular carcinoma is not yet recognized. Therefore, the present study was designed to assess the same. Results of gelatin zymography study showed that BA co-treatment significantly decreased the activities of MMP-2 and MMP-9, which is increased during hepatocellular carcinoma. Further immunoblot analysis showed decreased expression of MMP-2 and MMP-9 in rats co-treated with BA compared to DEN-induced hepatocellular carcinoma. Our results reveal that BA exerts its anti-metastatic effect against DEN-induced hepatocellular carcinoma by inhibiting the activities and expressions of MMP-2 and MMP-9. Copyright © 2010 John Wiley & Sons, Ltd." @default.
- W2067633335 created "2016-06-24" @default.
- W2067633335 creator A5029271574 @default.
- W2067633335 creator A5031538779 @default.
- W2067633335 creator A5038594015 @default.
- W2067633335 creator A5049846038 @default.
- W2067633335 creator A5091455987 @default.
- W2067633335 date "2010-03-01" @default.
- W2067633335 modified "2023-10-15" @default.
- W2067633335 title "Bacoside A downregulates matrix metalloproteinases 2 and 9 in DEN-induced hepatocellular carcinoma" @default.
- W2067633335 cites W1493277513 @default.
- W2067633335 cites W1605046409 @default.
- W2067633335 cites W1648100608 @default.
- W2067633335 cites W1965734230 @default.
- W2067633335 cites W1969133782 @default.
- W2067633335 cites W1974384889 @default.
- W2067633335 cites W1976831807 @default.
- W2067633335 cites W1984483611 @default.
- W2067633335 cites W1985550922 @default.
- W2067633335 cites W1991938154 @default.
- W2067633335 cites W1993920576 @default.
- W2067633335 cites W1996353122 @default.
- W2067633335 cites W1997383146 @default.
- W2067633335 cites W1998690998 @default.
- W2067633335 cites W2000754223 @default.
- W2067633335 cites W2003500892 @default.
- W2067633335 cites W2010715204 @default.
- W2067633335 cites W2011134969 @default.
- W2067633335 cites W2012041649 @default.
- W2067633335 cites W2015809080 @default.
- W2067633335 cites W2020519615 @default.
- W2067633335 cites W2020830322 @default.
- W2067633335 cites W2021159608 @default.
- W2067633335 cites W2026151657 @default.
- W2067633335 cites W2027072794 @default.
- W2067633335 cites W2035754366 @default.
- W2067633335 cites W2039585676 @default.
- W2067633335 cites W2042763933 @default.
- W2067633335 cites W2047089814 @default.
- W2067633335 cites W2052608330 @default.
- W2067633335 cites W2053560785 @default.
- W2067633335 cites W2060960573 @default.
- W2067633335 cites W2072783120 @default.
- W2067633335 cites W2073079990 @default.
- W2067633335 cites W2080765501 @default.
- W2067633335 cites W2091173213 @default.
- W2067633335 cites W2092816381 @default.
- W2067633335 cites W2119823629 @default.
- W2067633335 cites W2120169362 @default.
- W2067633335 cites W2124076790 @default.
- W2067633335 cites W2124392946 @default.
- W2067633335 cites W2134580064 @default.
- W2067633335 cites W2136880181 @default.
- W2067633335 cites W2137673908 @default.
- W2067633335 cites W2146564308 @default.
- W2067633335 cites W2158132102 @default.
- W2067633335 cites W2165234889 @default.
- W2067633335 cites W2406846059 @default.
- W2067633335 cites W2417464447 @default.
- W2067633335 cites W2465779665 @default.
- W2067633335 cites W277597119 @default.
- W2067633335 doi "https://doi.org/10.1002/cbf.1638" @default.
- W2067633335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20084675" @default.
- W2067633335 hasPublicationYear "2010" @default.
- W2067633335 type Work @default.
- W2067633335 sameAs 2067633335 @default.
- W2067633335 citedByCount "22" @default.
- W2067633335 countsByYear W20676333352012 @default.
- W2067633335 countsByYear W20676333352013 @default.
- W2067633335 countsByYear W20676333352015 @default.
- W2067633335 countsByYear W20676333352017 @default.
- W2067633335 countsByYear W20676333352018 @default.
- W2067633335 countsByYear W20676333352019 @default.
- W2067633335 countsByYear W20676333352020 @default.
- W2067633335 countsByYear W20676333352022 @default.
- W2067633335 countsByYear W20676333352023 @default.
- W2067633335 crossrefType "journal-article" @default.
- W2067633335 hasAuthorship W2067633335A5029271574 @default.
- W2067633335 hasAuthorship W2067633335A5031538779 @default.
- W2067633335 hasAuthorship W2067633335A5038594015 @default.
- W2067633335 hasAuthorship W2067633335A5049846038 @default.
- W2067633335 hasAuthorship W2067633335A5091455987 @default.
- W2067633335 hasConcept C109523444 @default.
- W2067633335 hasConcept C121608353 @default.
- W2067633335 hasConcept C126322002 @default.
- W2067633335 hasConcept C143998085 @default.
- W2067633335 hasConcept C177430391 @default.
- W2067633335 hasConcept C2776231280 @default.
- W2067633335 hasConcept C2777546739 @default.
- W2067633335 hasConcept C2778019345 @default.
- W2067633335 hasConcept C2779013556 @default.
- W2067633335 hasConcept C502942594 @default.
- W2067633335 hasConcept C71924100 @default.
- W2067633335 hasConceptScore W2067633335C109523444 @default.
- W2067633335 hasConceptScore W2067633335C121608353 @default.
- W2067633335 hasConceptScore W2067633335C126322002 @default.
- W2067633335 hasConceptScore W2067633335C143998085 @default.
- W2067633335 hasConceptScore W2067633335C177430391 @default.