Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067635268> ?p ?o ?g. }
- W2067635268 abstract "Abstract Background The Kit gene encodes a receptor tyrosine kinase involved in various biological processes including melanogenesis, hematopoiesis and gametogenesis in mice and human. A large number of Kit mutants has been described so far showing the pleiotropic phenotypes associated with partial loss-of-function of the gene. Hypomorphic mutations can induce a light coat color phenotype while complete lack of KIT function interferes with embryogenesis. Interestingly several intermediate hypomorphic mutations induced in addition growth retardation and post-natal mortality. Results In this report we investigated the post-natal role of Kit by using a panel of chemically-induced hypomorphic mutations recently isolated in the mouse. We found that, in addition to the classical phenotypes, mutations of Kit induced juvenile steatosis, associated with the downregulation of the three genes, VldlR , Lpin1 and Lpl , controlling lipid metabolism in the post-natal liver. Hence, Kit loss-of-functions mimicked the inactivation of genes controlling the hepatic metabolism of triglycerides, the major source of energy from maternal milk, leading to growth and viability defects during neonatal development. Conclusion This is a first report involving KIT in the control of lipid metabolism in neonates and opening new perspectives for understanding juvenile steatosis. Moreover, it reinforces the role of Kit during development of the liver and underscores the caution that should be exerted in using KIT inhibitors during anti-cancer treatment." @default.
- W2067635268 created "2016-06-24" @default.
- W2067635268 creator A5001861468 @default.
- W2067635268 creator A5004472037 @default.
- W2067635268 creator A5015006216 @default.
- W2067635268 creator A5030493825 @default.
- W2067635268 creator A5034230757 @default.
- W2067635268 creator A5035161055 @default.
- W2067635268 creator A5043957093 @default.
- W2067635268 creator A5048195537 @default.
- W2067635268 creator A5050613488 @default.
- W2067635268 creator A5072081106 @default.
- W2067635268 creator A5075100081 @default.
- W2067635268 creator A5078237152 @default.
- W2067635268 creator A5084652920 @default.
- W2067635268 creator A5089683997 @default.
- W2067635268 creator A5089830154 @default.
- W2067635268 date "2007-07-05" @default.
- W2067635268 modified "2023-10-18" @default.
- W2067635268 title "KIT is required for hepatic function during mouse post-natal development" @default.
- W2067635268 cites W125562053 @default.
- W2067635268 cites W1264786469 @default.
- W2067635268 cites W1523366628 @default.
- W2067635268 cites W1560994819 @default.
- W2067635268 cites W1565399287 @default.
- W2067635268 cites W1864063551 @default.
- W2067635268 cites W1872667540 @default.
- W2067635268 cites W1926039932 @default.
- W2067635268 cites W1934287581 @default.
- W2067635268 cites W1965051817 @default.
- W2067635268 cites W1965848933 @default.
- W2067635268 cites W1968547228 @default.
- W2067635268 cites W1972797928 @default.
- W2067635268 cites W1975368252 @default.
- W2067635268 cites W1976061474 @default.
- W2067635268 cites W1982231225 @default.
- W2067635268 cites W1983376590 @default.
- W2067635268 cites W1988821060 @default.
- W2067635268 cites W1989558547 @default.
- W2067635268 cites W1991175004 @default.
- W2067635268 cites W1998104707 @default.
- W2067635268 cites W1998242889 @default.
- W2067635268 cites W1998666537 @default.
- W2067635268 cites W2003864330 @default.
- W2067635268 cites W2005320735 @default.
- W2067635268 cites W2006470548 @default.
- W2067635268 cites W2010684388 @default.
- W2067635268 cites W2012023068 @default.
- W2067635268 cites W2012354624 @default.
- W2067635268 cites W2031886869 @default.
- W2067635268 cites W2033509429 @default.
- W2067635268 cites W2034308910 @default.
- W2067635268 cites W2037514075 @default.
- W2067635268 cites W2037846513 @default.
- W2067635268 cites W2038363960 @default.
- W2067635268 cites W2040427109 @default.
- W2067635268 cites W2041415161 @default.
- W2067635268 cites W2041920247 @default.
- W2067635268 cites W2049314578 @default.
- W2067635268 cites W2054113364 @default.
- W2067635268 cites W2063436204 @default.
- W2067635268 cites W2064254523 @default.
- W2067635268 cites W2064280522 @default.
- W2067635268 cites W2064934740 @default.
- W2067635268 cites W2070076558 @default.
- W2067635268 cites W2071725100 @default.
- W2067635268 cites W2076947916 @default.
- W2067635268 cites W2077443491 @default.
- W2067635268 cites W2089441009 @default.
- W2067635268 cites W2093711908 @default.
- W2067635268 cites W2097161121 @default.
- W2067635268 cites W2098904004 @default.
- W2067635268 cites W2102651270 @default.
- W2067635268 cites W2103414247 @default.
- W2067635268 cites W2104441503 @default.
- W2067635268 cites W2105470428 @default.
- W2067635268 cites W2107705298 @default.
- W2067635268 cites W2109896814 @default.
- W2067635268 cites W2110018457 @default.
- W2067635268 cites W2112811492 @default.
- W2067635268 cites W2113553015 @default.
- W2067635268 cites W2118218845 @default.
- W2067635268 cites W2118460316 @default.
- W2067635268 cites W2120060713 @default.
- W2067635268 cites W2120064298 @default.
- W2067635268 cites W2131970062 @default.
- W2067635268 cites W2132468746 @default.
- W2067635268 cites W2144512169 @default.
- W2067635268 cites W2145398665 @default.
- W2067635268 cites W2149130539 @default.
- W2067635268 cites W2150769574 @default.
- W2067635268 cites W2154171026 @default.
- W2067635268 cites W2156274208 @default.
- W2067635268 cites W2160518844 @default.
- W2067635268 cites W2162359545 @default.
- W2067635268 cites W2164559539 @default.
- W2067635268 cites W2164872793 @default.
- W2067635268 cites W2171188320 @default.
- W2067635268 cites W2244716392 @default.
- W2067635268 cites W2342825661 @default.