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- W2067640929 abstract "The relative roles of the extrapyramidal and mesolimbic areas in the catecholaminergic-cholinergic control of catalepsy were investigated by assessment of the effects of disruption to catecholaminergic systems using α-methylparatyrosine and by surgical lesion of the ascending dopaminergic pathways to the extrapyramidal and/or mesolimbic brain areas upon neuroleptic and cholinergic catalepsy. α-Methylparatyrosine pretreatment was shown to enhance both neuroleptic (haloperidol, fluphenazine, clothiapine, oxypertine and clozapine) and cholinergic (arecoline and RS86) catalepsy. Lesions placed either to interrupt both extrapyramidal and mesolimbic dopaminergic afferents or to interrupt only the innervation to the mesolimbic nuclei caused an initial potentiation followed by a reduction in the cataleptic effects of the neuroleptic agents but caused potentiation of cholinergic catalepsy at all times of testing. The results are interpreted as supporting a dopaminergic-cholinergic balanced control of catalepsy which involves not only the extrapyramidal but also the mesolimbic dopaminergic systems." @default.
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- W2067640929 title "The importance of the ascending dopaminergic systems to the extrapyramidal and mesolimbic brain areas for the cataleptic action of the neuroleptic and cholinergic agents" @default.
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- W2067640929 doi "https://doi.org/10.1016/0028-3908(74)90118-x" @default.
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