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• W2067641190 abstract "Background. Pharmacological and neurodevelopmental data support the idea that the gene, which codes for the 5-HT5A receptor is an important candidate gene for schizophrenia susceptibility. However, previous genetic studies focusing on this gene yielded conflicting results, potentially because of: (i) stratification biases of case-control association studies, (ii) genetic and phenotypic heterogeneity of schizophrenia, and (iii) variability in the loci analyzed (the 5-HT5A gene having many polymorphic sites). Methods. A transmission disequilibrium test was used in the present study aimed at investigating two polymorphisms in exon 1 of the 5-HT5A gene, the A12T silent substitution and the C43T transversion leading to a 15Pro → Ser substitution, in 103 patients with DSM-IV diagnosis of schizophrenia, and their 206 parents. Results. We found an excess of transmission of the 12T allele from the parents to their affected children (P=0.02), with evidence for linkage disequilibrium between the 12T–43C haplotype and schizophrenia (P=0.002). Furthermore, patients with the 12T allele had a significantly later age at onset (P=0.003), and the Q-TDT approach confirmed that this allele was transmitted with an older age at onset (P=0.01). Conclusions. These data provided convergent evidence for a significant role of the 5-HT5A gene in schizophrenia and more specifically in patients with later age at onset." @default.
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• W2067641190 date "2004-07-01" @default.
• W2067641190 modified "2023-10-16" @default.
• W2067641190 title "Family-based association studies between 5-HT5A receptor gene and schizophrenia" @default.
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• W2067641190 doi "https://doi.org/10.1016/j.jpsychires.2004.01.002" @default.
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