FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067654583> ?p ?o ?g. }

• W2067654583 endingPage "231" @default.
• W2067654583 startingPage "220" @default.
• W2067654583 abstract "Mutations of the ENPP1 gene encoding ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) are associated with medial calcification in infancy. While the inhibitory role of matrix proteins such as osteopontin (OPN) with respect to atherosclerotic plaque calcification has been established, the role of NPP1 in plaque calcification is not known. We assessed the degree of plaque calcification (computed tomography), NPP1 and OPN localization (immunohistochemistry) and expression (RT-PCR) in a cohort of 45 patients undergoing carotid endatherectomy for significant stenosis of the internal carotid artery and in normal arteries (N= 50). We correlated NPP1 and OPN expression levels to the degree of plaque calcification, to pro-atherogenic factors and statin therapy. NPP1 was demonstrated in the base and in the shoulder of atherosclerotic plaques. Compared to normal arteries and non-calcified plaques, in calcified plaques NPP1 mRNA was decreased (P < 0.0001). OPN mRNA levels were up-regulated in carotid atheroma. NPP1 and OPN expression levels positively correlated with the degree of plaque calcification (R= 0.54, P= 0.00019 and R= 0.46, P= 0.017, respectively) and with risk factors of atherosclerosis. Expression of the calcification inhibitor NPP1 is down-regulated in calcified atherosclerotic plaques. Our correlation data point to a counter-active mechanism, which in the end turns out to be insufficient to prevent further progression of calcification." @default.
• W2067654583 created "2016-06-24" @default.
• W2067654583 creator A5004810639 @default.
• W2067654583 creator A5005879874 @default.
• W2067654583 creator A5009379317 @default.
• W2067654583 creator A5017232127 @default.
• W2067654583 creator A5061411369 @default.
• W2067654583 creator A5064980760 @default.
• W2067654583 creator A5080099018 @default.
• W2067654583 date "2011-02-01" @default.
• W2067654583 modified "2023-10-17" @default.
• W2067654583 title "Expression of NPP1 is regulated during atheromatous plaque calcification" @default.
• W2067654583 cites W1502955608 @default.
• W2067654583 cites W1517490828 @default.
• W2067654583 cites W1556857132 @default.
• W2067654583 cites W1965619867 @default.
• W2067654583 cites W1966174617 @default.
• W2067654583 cites W1971037281 @default.
• W2067654583 cites W1980769406 @default.
• W2067654583 cites W1989934799 @default.
• W2067654583 cites W2005537600 @default.
• W2067654583 cites W2012762896 @default.
• W2067654583 cites W2018587528 @default.
• W2067654583 cites W2018599017 @default.
• W2067654583 cites W2020967841 @default.
• W2067654583 cites W2033568177 @default.
• W2067654583 cites W2039680865 @default.
• W2067654583 cites W2046349924 @default.
• W2067654583 cites W2051625732 @default.
• W2067654583 cites W2052561221 @default.
• W2067654583 cites W2056421295 @default.
• W2067654583 cites W2057555472 @default.
• W2067654583 cites W2070274839 @default.
• W2067654583 cites W2075377475 @default.
• W2067654583 cites W2076225138 @default.
• W2067654583 cites W2081291016 @default.
• W2067654583 cites W2094737433 @default.
• W2067654583 cites W2105430996 @default.
• W2067654583 cites W2108284627 @default.
• W2067654583 cites W2112692194 @default.
• W2067654583 cites W2114721006 @default.
• W2067654583 cites W2116381107 @default.
• W2067654583 cites W2121790695 @default.
• W2067654583 cites W2124309684 @default.
• W2067654583 cites W2132677377 @default.
• W2067654583 cites W2139032200 @default.
• W2067654583 cites W2145241437 @default.
• W2067654583 cites W2148413329 @default.
• W2067654583 cites W2154274736 @default.
• W2067654583 cites W2157224349 @default.
• W2067654583 cites W2163408805 @default.
• W2067654583 cites W2408330233 @default.
• W2067654583 cites W4251311170 @default.
• W2067654583 doi "https://doi.org/10.1111/j.1582-4934.2009.00988.x" @default.
• W2067654583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3822790" @default.
• W2067654583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20015201" @default.
• W2067654583 hasPublicationYear "2011" @default.
• W2067654583 type Work @default.
• W2067654583 sameAs 2067654583 @default.
• W2067654583 citedByCount "18" @default.
• W2067654583 countsByYear W20676545832012 @default.
• W2067654583 countsByYear W20676545832013 @default.
• W2067654583 countsByYear W20676545832014 @default.
• W2067654583 countsByYear W20676545832016 @default.
• W2067654583 countsByYear W20676545832017 @default.
• W2067654583 countsByYear W20676545832018 @default.
• W2067654583 countsByYear W20676545832019 @default.
• W2067654583 countsByYear W20676545832021 @default.
• W2067654583 countsByYear W20676545832023 @default.
• W2067654583 crossrefType "journal-article" @default.
• W2067654583 hasAuthorship W2067654583A5004810639 @default.
• W2067654583 hasAuthorship W2067654583A5005879874 @default.
• W2067654583 hasAuthorship W2067654583A5009379317 @default.
• W2067654583 hasAuthorship W2067654583A5017232127 @default.
• W2067654583 hasAuthorship W2067654583A5061411369 @default.
• W2067654583 hasAuthorship W2067654583A5064980760 @default.
• W2067654583 hasAuthorship W2067654583A5080099018 @default.
• W2067654583 hasBestOaLocation W20676545831 @default.
• W2067654583 hasConcept C126322002 @default.
• W2067654583 hasConcept C142724271 @default.
• W2067654583 hasConcept C2775981168 @default.
• W2067654583 hasConcept C2779318932 @default.
• W2067654583 hasConcept C2780309369 @default.
• W2067654583 hasConcept C2780804394 @default.
• W2067654583 hasConcept C71924100 @default.
• W2067654583 hasConceptScore W2067654583C126322002 @default.
• W2067654583 hasConceptScore W2067654583C142724271 @default.
• W2067654583 hasConceptScore W2067654583C2775981168 @default.
• W2067654583 hasConceptScore W2067654583C2779318932 @default.
• W2067654583 hasConceptScore W2067654583C2780309369 @default.
• W2067654583 hasConceptScore W2067654583C2780804394 @default.
• W2067654583 hasConceptScore W2067654583C71924100 @default.
• W2067654583 hasIssue "2" @default.
• W2067654583 hasLocation W20676545831 @default.
• W2067654583 hasLocation W20676545832 @default.
• W2067654583 hasLocation W20676545833 @default.
• W2067654583 hasLocation W20676545834 @default.
• W2067654583 hasOpenAccess W2067654583 @default.

• next