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- W2067656670 abstract "Abstract It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia. A 67‐year‐old woman with symptomatic epilepsy since age 6 years, classified as Lennox–Gasteau syndrome, developed severe, isolated thrombocytopenia of 5 GIGA/L (normal: 150–360 GIGA/L) after being on CBZ (1200 mg/day) for 15 days and additional VPA (300 mg/day) for 5 days in combination. After discontinuation of CBZ and VPA and two thrombocyte transfusions, the thrombocyte count normalized within 3 days. Because she had been taking VPA for only 5 days in addition to CBZ, it could not be confirmed whether it was CBZ alone or the combination of CBZ and VPA that was responsible for the severe thrombocytopenia." @default.
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- W2067656670 date "2001-08-01" @default.
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- W2067656670 title "Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate" @default.
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- W2067656670 doi "https://doi.org/10.1046/j.1440-1819.2001.00885.x" @default.
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