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• W2067662371 startingPage "2931" @default.
• W2067662371 abstract "BRCA1, a product of a familial breast and ovarian cancer susceptibility gene, localizes to centrosomes and physically interacts with γ-tubulin, a key centrosomal protein for microtubule nucleation and anchoring at centrosomes. Here, we performed a rigorous analysis of centrosome localization of BRCA1, and found that BRCA1 is specifically associated with mother centrioles in unduplicated centrosomes, and daughter centrioles acquire BRCA1 prior to initiation of duplication, and thus duplicated centrosomes are both bound by BRCA1. We further found that BRCA1 suppresses centrosomal aster formation. In addition, we identified a new domain of BRCA1 critical for γ-tubulin binding, which confers not only its localization to centrosomes, but also its activity to suppress centrosomal aster formation." @default.
• W2067662371 created "2016-06-24" @default.
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• W2067662371 creator A5041409646 @default.
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• W2067662371 date "2012-08-01" @default.
• W2067662371 modified "2023-09-25" @default.
• W2067662371 title "Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation" @default.
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• W2067662371 doi "https://doi.org/10.4161/cc.21396" @default.
• W2067662371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419063" @default.
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