FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067668846> ?p ?o ?g. }

• W2067668846 endingPage "905" @default.
• W2067668846 startingPage "892" @default.
• W2067668846 abstract "Pyramidal neurons from the hippocampus undergo a well characterized programme of differentiation in vitro involving five distinct stages (1–5). While some important aspects of the dynamic organization of cell cytoplasmic structure that underlie neuronal polarization have been elucidated, little is known about corresponding changes in nuclear organization. Here we identify major changes affecting nuclear structure and gene expression during late stages of differentiation. At stage 4 a sustained increase in global transcriptional activity occurs. This is followed at stage 5 by proliferation of coiled bodies, i.e. subnuclear organelles containing splicing factors, which form a novel domain around the nucleolus that we refer to as the rosette. Both the morphology and timing of rosette formation are identical in neurons in vitro and in situ in the developing hippocampus in rat brain. Long-term synaptic inhibition in vitro or growth at low density does not prevent either nuclear reorganization, enhanced transcriptional activity or the formation of pre-synaptic specializations. These data indicate that stage-specific changes in nuclear structure and function, similar to distinct rearrangements of cytoplasmic components, are pre-programmed aspects of the neuronal differentiation pathway in the hippocampus." @default.
• W2067668846 created "2016-06-24" @default.
• W2067668846 creator A5014112981 @default.
• W2067668846 creator A5082386753 @default.
• W2067668846 creator A5082968855 @default.
• W2067668846 date "1996-05-01" @default.
• W2067668846 modified "2023-10-11" @default.
• W2067668846 title "Neuronal Differentiation in the Rat Hippocampus Involves a Stage-specific Reorganization of Subnuclear Structure both<i>In Vivo</i>and<i>In Vitro</i>" @default.
• W2067668846 cites W1494605757 @default.
• W2067668846 cites W1529048149 @default.
• W2067668846 cites W1531621505 @default.
• W2067668846 cites W1584569428 @default.
• W2067668846 cites W1752028172 @default.
• W2067668846 cites W1895213472 @default.
• W2067668846 cites W1968951620 @default.
• W2067668846 cites W1969577392 @default.
• W2067668846 cites W1970409943 @default.
• W2067668846 cites W1974814389 @default.
• W2067668846 cites W1974881281 @default.
• W2067668846 cites W1977509652 @default.
• W2067668846 cites W1977944225 @default.
• W2067668846 cites W1979629971 @default.
• W2067668846 cites W1980408287 @default.
• W2067668846 cites W1986130768 @default.
• W2067668846 cites W1998225973 @default.
• W2067668846 cites W1999284679 @default.
• W2067668846 cites W2008244701 @default.
• W2067668846 cites W2010465386 @default.
• W2067668846 cites W2014531915 @default.
• W2067668846 cites W2033188783 @default.
• W2067668846 cites W2036512556 @default.
• W2067668846 cites W2038236063 @default.
• W2067668846 cites W2042710357 @default.
• W2067668846 cites W2057893242 @default.
• W2067668846 cites W2059053306 @default.
• W2067668846 cites W2067382966 @default.
• W2067668846 cites W2067574987 @default.
• W2067668846 cites W2069725464 @default.
• W2067668846 cites W2071971527 @default.
• W2067668846 cites W2075479076 @default.
• W2067668846 cites W2078084904 @default.
• W2067668846 cites W2078837666 @default.
• W2067668846 cites W2092400927 @default.
• W2067668846 cites W2093230613 @default.
• W2067668846 cites W2104618420 @default.
• W2067668846 cites W2106306817 @default.
• W2067668846 cites W2125763225 @default.
• W2067668846 cites W2129995902 @default.
• W2067668846 cites W2130657959 @default.
• W2067668846 cites W2143062333 @default.
• W2067668846 cites W2150562155 @default.
• W2067668846 cites W2152464785 @default.
• W2067668846 cites W2153542488 @default.
• W2067668846 cites W2159201176 @default.
• W2067668846 cites W2164477294 @default.
• W2067668846 cites W2167356244 @default.
• W2067668846 cites W2178814694 @default.
• W2067668846 cites W2182184745 @default.
• W2067668846 cites W2313254115 @default.
• W2067668846 cites W4238839969 @default.
• W2067668846 doi "https://doi.org/10.1111/j.1460-9568.1996.tb01576.x" @default.
• W2067668846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8743737" @default.
• W2067668846 hasPublicationYear "1996" @default.
• W2067668846 type Work @default.
• W2067668846 sameAs 2067668846 @default.
• W2067668846 citedByCount "37" @default.
• W2067668846 countsByYear W20676688462013 @default.
• W2067668846 countsByYear W20676688462016 @default.
• W2067668846 countsByYear W20676688462018 @default.
• W2067668846 countsByYear W20676688462022 @default.
• W2067668846 countsByYear W20676688462023 @default.
• W2067668846 crossrefType "journal-article" @default.
• W2067668846 hasAuthorship W2067668846A5014112981 @default.
• W2067668846 hasAuthorship W2067668846A5082386753 @default.
• W2067668846 hasAuthorship W2067668846A5082968855 @default.
• W2067668846 hasConcept C104317684 @default.
• W2067668846 hasConcept C148738053 @default.
• W2067668846 hasConcept C169760540 @default.
• W2067668846 hasConcept C2781161787 @default.
• W2067668846 hasConcept C54355233 @default.
• W2067668846 hasConcept C86803240 @default.
• W2067668846 hasConcept C95444343 @default.
• W2067668846 hasConceptScore W2067668846C104317684 @default.
• W2067668846 hasConceptScore W2067668846C148738053 @default.
• W2067668846 hasConceptScore W2067668846C169760540 @default.
• W2067668846 hasConceptScore W2067668846C2781161787 @default.
• W2067668846 hasConceptScore W2067668846C54355233 @default.
• W2067668846 hasConceptScore W2067668846C86803240 @default.
• W2067668846 hasConceptScore W2067668846C95444343 @default.
• W2067668846 hasIssue "5" @default.
• W2067668846 hasLocation W20676688461 @default.
• W2067668846 hasLocation W20676688462 @default.
• W2067668846 hasOpenAccess W2067668846 @default.
• W2067668846 hasPrimaryLocation W20676688461 @default.
• W2067668846 hasRelatedWork W1641042124 @default.
• W2067668846 hasRelatedWork W1990804418 @default.
• W2067668846 hasRelatedWork W1993764875 @default.
• W2067668846 hasRelatedWork W2013243191 @default.

• next