FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067681539> ?p ?o ?g. }

• W2067681539 endingPage "C1384" @default.
• W2067681539 startingPage "C1373" @default.
• W2067681539 abstract "Norepinephrine (NE) induces endoplasmic reticulum (ER) unfolded protein response and reduces maturation and translocation of NE transporter to cell membrane via enhanced formation of reactive oxygen species in PC-12 cells. In the present study, we investigated whether ER stress is also implicated in the proapoptotic effect of NE. We found that the apoptotic effect of NE was associated with increased processing of ER-resident pro-caspase-12, cleavage of caspase-9 and -3, and mitochondrial release of cytochrome c. ER stress was evidenced by upregulation of ER chaperone GRP78 and transcription factor CHOP and the translocation of XBP-1 from the ER to the nucleus by NE. NE also reduced phospho-Akt (Ser473), indicating suppression of the phosphatidylinositol 3-kinase (PI3-kinase)/Akt survival pathway. Similar results were produced by thapsigargin. NGF, which promotes the PI3-kinase/Akt activity, reduced the effects of NE and thapsigargin on apoptosis and activation of caspase-12 and -3. However, the effects of NE, but not of thapsigargin, were abolished by pretreatment with SOD and catalase. In contrast, the PI3-kinase inhibitors LY-294002 and wortmannin abolished the protective effects of both SOD/catalase and NGF on NE-induced apoptosis. The functional importance of caspase-12 activation was supported by the use of Z-ATAD-FMK, which reduced the NE-induced processing of caspase-12 and cell apoptosis, but the caspase-12, -9, and -3 inhibitors had no effects on the increase in cytosolic cytochrome c produced by NE. In contrast, the release of mitochondrial cytochrome c was abolished by SOD/catalase and NGF. These results indicate that NE induced cell apoptosis by both ER stress and a mitochondrial death pathway and that the effects of NE were mediated via oxidative stress and inhibition of the PI3-kinase/Akt survival pathway." @default.
• W2067681539 created "2016-06-24" @default.
• W2067681539 creator A5028290238 @default.
• W2067681539 creator A5041021400 @default.
• W2067681539 creator A5061307181 @default.
• W2067681539 creator A5073009972 @default.
• W2067681539 creator A5075118408 @default.
• W2067681539 date "2006-05-01" @default.
• W2067681539 modified "2023-10-18" @default.
• W2067681539 title "Norepinephrine-induced oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of phosphatidylinositol 3-kinase survival pathway" @default.
• W2067681539 cites W1528368632 @default.
• W2067681539 cites W1529396499 @default.
• W2067681539 cites W1545503281 @default.
• W2067681539 cites W1754337642 @default.
• W2067681539 cites W1964231591 @default.
• W2067681539 cites W1964685161 @default.
• W2067681539 cites W1973508937 @default.
• W2067681539 cites W1980837164 @default.
• W2067681539 cites W1984611855 @default.
• W2067681539 cites W1985339713 @default.
• W2067681539 cites W1992051618 @default.
• W2067681539 cites W1993216157 @default.
• W2067681539 cites W1996076769 @default.
• W2067681539 cites W2006334817 @default.
• W2067681539 cites W2009653945 @default.
• W2067681539 cites W2013065884 @default.
• W2067681539 cites W2013103361 @default.
• W2067681539 cites W2024306318 @default.
• W2067681539 cites W2032471392 @default.
• W2067681539 cites W2034213169 @default.
• W2067681539 cites W2038551082 @default.
• W2067681539 cites W2039698012 @default.
• W2067681539 cites W2047758994 @default.
• W2067681539 cites W2054930867 @default.
• W2067681539 cites W2057064063 @default.
• W2067681539 cites W2058138221 @default.
• W2067681539 cites W2059898034 @default.
• W2067681539 cites W2064086920 @default.
• W2067681539 cites W2064950130 @default.
• W2067681539 cites W2067701929 @default.
• W2067681539 cites W2069924169 @default.
• W2067681539 cites W2076901302 @default.
• W2067681539 cites W2078532650 @default.
• W2067681539 cites W2080901528 @default.
• W2067681539 cites W2091467934 @default.
• W2067681539 cites W2097767970 @default.
• W2067681539 cites W2098781316 @default.
• W2067681539 cites W2103734702 @default.
• W2067681539 cites W2104790095 @default.
• W2067681539 cites W2107160851 @default.
• W2067681539 cites W2107601804 @default.
• W2067681539 cites W2115205812 @default.
• W2067681539 cites W2132304671 @default.
• W2067681539 cites W2133425838 @default.
• W2067681539 cites W2133451731 @default.
• W2067681539 cites W2137035181 @default.
• W2067681539 cites W2138431969 @default.
• W2067681539 cites W2147091068 @default.
• W2067681539 cites W2149500786 @default.
• W2067681539 cites W2149721868 @default.
• W2067681539 cites W2152522654 @default.
• W2067681539 cites W2345912369 @default.
• W2067681539 doi "https://doi.org/10.1152/ajpcell.00369.2005" @default.
• W2067681539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16338971" @default.
• W2067681539 hasPublicationYear "2006" @default.
• W2067681539 type Work @default.
• W2067681539 sameAs 2067681539 @default.
• W2067681539 citedByCount "40" @default.
• W2067681539 countsByYear W20676815392012 @default.
• W2067681539 countsByYear W20676815392013 @default.
• W2067681539 countsByYear W20676815392014 @default.
• W2067681539 countsByYear W20676815392015 @default.
• W2067681539 countsByYear W20676815392016 @default.
• W2067681539 countsByYear W20676815392019 @default.
• W2067681539 countsByYear W20676815392021 @default.
• W2067681539 countsByYear W20676815392022 @default.
• W2067681539 countsByYear W20676815392023 @default.
• W2067681539 crossrefType "journal-article" @default.
• W2067681539 hasAuthorship W2067681539A5028290238 @default.
• W2067681539 hasAuthorship W2067681539A5041021400 @default.
• W2067681539 hasAuthorship W2067681539A5061307181 @default.
• W2067681539 hasAuthorship W2067681539A5073009972 @default.
• W2067681539 hasAuthorship W2067681539A5075118408 @default.
• W2067681539 hasConcept C12519072 @default.
• W2067681539 hasConcept C139447449 @default.
• W2067681539 hasConcept C158617107 @default.
• W2067681539 hasConcept C184235292 @default.
• W2067681539 hasConcept C185592680 @default.
• W2067681539 hasConcept C190283241 @default.
• W2067681539 hasConcept C2777146706 @default.
• W2067681539 hasConcept C2778308172 @default.
• W2067681539 hasConcept C2780610907 @default.
• W2067681539 hasConcept C28859421 @default.
• W2067681539 hasConcept C29311851 @default.
• W2067681539 hasConcept C31573885 @default.
• W2067681539 hasConcept C55493867 @default.
• W2067681539 hasConcept C62478195 @default.
• W2067681539 hasConcept C75217442 @default.

• next