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• W2067682110 abstract "The Ca2+ channel blocker D-600 (methoxyverapamil) paralyses single muscle fibres of the frog: fibres exposed to the drug at 7 degrees C give a single K+ contracture after which they are paralysed, unable to contract in response to electrical stimulation or further applications of K+. Paralysed fibres contract in response to caffeine and have normal resting potentials and action potentials. Fibres treated with D-600 at 22 degrees C are not paralysed. Paralysed fibres warmed to 22 degrees C recover contractile properties: they twitch and give K+ contractures. Other workers have shown that D-600 blocks a Ca2+ channel at room temperature; thus, the paralytic action of D-600 is probably mediated by a different membrane protein, perhaps a different Ca2+ channel from that blocked at room temperature. These results suggest that the binding of D-600 can disrupt the mechanism coupling electrical potential changes across the T membrane to Ca2+ release from the sarcoplasmic reticulum." @default.
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• W2067682110 date "1983-08-01" @default.
• W2067682110 modified "2023-10-10" @default.
• W2067682110 title "Paralysis of frog skeletal muscle fibres by the calcium antagonist D-600." @default.
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• W2067682110 doi "https://doi.org/10.1113/jphysiol.1983.sp014819" @default.
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