FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067682358> ?p ?o ?g. }

• W2067682358 endingPage "e27033" @default.
• W2067682358 startingPage "e27033" @default.
• W2067682358 abstract "Microbes respond to changing environments by adjusting gene expression levels to the demand for the corresponding proteins. Adjusting protein levels is slow, consequently cells may reach the optimal protein level only by a time when the demand changed again. It is therefore not a priori clear whether expression on demand is always the optimal strategy. Indeed, many genes are constitutively expressed at intermediate levels, which represents a permanent cost but provides an immediate benefit when the protein is needed. Which are the conditions that select for a responsive or a constitutive expression strategy, what determines the optimal constitutive expression level in a changing environment, and how is the fitness of the two strategies affected by gene expression noise? Based on an established model of the lac- and gal-operon expression dynamics, we study the fitness of a constitutive and a responsive expression strategy in time-varying environments. We find that the optimal constitutive expression level differs from the average demand for the gene product and from the average optimal expression level; depending on the shape of the growth rate function, the optimal expression level either provides intermediate fitness in all environments, or maximizes fitness in only one of them. We find that constitutive expression can provide higher fitness than responsive expression even when regulatory machinery comes at no cost, and we determine the minimal response rate necessary for expression on demand to confer a benefit. Environmental and inter-cellular noise favor the responsive strategy while reducing fitness of the constitutive one. Our results show the interplay between the demand-frequency for a gene product, the genetic response rate, and the fitness, and address important questions on the evolution of gene regulation. Some of our predictions agree with recent yeast high throughput data, for others we propose the experiments that are needed to verify them." @default.
• W2067682358 created "2016-06-24" @default.
• W2067682358 creator A5048042845 @default.
• W2067682358 date "2011-11-30" @default.
• W2067682358 modified "2023-10-13" @default.
• W2067682358 title "Constitutive versus Responsive Gene Expression Strategies for Growth in Changing Environments" @default.
• W2067682358 cites W1563526939 @default.
• W2067682358 cites W1968066742 @default.
• W2067682358 cites W1970970926 @default.
• W2067682358 cites W1976971043 @default.
• W2067682358 cites W1981556824 @default.
• W2067682358 cites W1985002373 @default.
• W2067682358 cites W1986887287 @default.
• W2067682358 cites W1993009001 @default.
• W2067682358 cites W1999777663 @default.
• W2067682358 cites W2002596897 @default.
• W2067682358 cites W2009825380 @default.
• W2067682358 cites W2011020249 @default.
• W2067682358 cites W2026148048 @default.
• W2067682358 cites W2028979517 @default.
• W2067682358 cites W2031822229 @default.
• W2067682358 cites W2033417473 @default.
• W2067682358 cites W2037768790 @default.
• W2067682358 cites W2040889971 @default.
• W2067682358 cites W2042231801 @default.
• W2067682358 cites W2043487490 @default.
• W2067682358 cites W2044692345 @default.
• W2067682358 cites W2057107775 @default.
• W2067682358 cites W2068872007 @default.
• W2067682358 cites W2075329036 @default.
• W2067682358 cites W2083581925 @default.
• W2067682358 cites W2096015757 @default.
• W2067682358 cites W2103029515 @default.
• W2067682358 cites W2113643142 @default.
• W2067682358 cites W2118274513 @default.
• W2067682358 cites W2121218602 @default.
• W2067682358 cites W2121633536 @default.
• W2067682358 cites W2122575278 @default.
• W2067682358 cites W2126608070 @default.
• W2067682358 cites W2126733261 @default.
• W2067682358 cites W2127013070 @default.
• W2067682358 cites W2127240867 @default.
• W2067682358 cites W2134809769 @default.
• W2067682358 cites W2135329955 @default.
• W2067682358 cites W2136498480 @default.
• W2067682358 cites W2139500219 @default.
• W2067682358 cites W2142373389 @default.
• W2067682358 cites W2144620146 @default.
• W2067682358 cites W2145750053 @default.
• W2067682358 cites W2148323109 @default.
• W2067682358 cites W2159760074 @default.
• W2067682358 cites W2162884852 @default.
• W2067682358 cites W2165081628 @default.
• W2067682358 cites W2171280873 @default.
• W2067682358 cites W2171769276 @default.
• W2067682358 cites W3099697202 @default.
• W2067682358 cites W3104756019 @default.
• W2067682358 doi "https://doi.org/10.1371/journal.pone.0027033" @default.
• W2067682358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3227599" @default.
• W2067682358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22140435" @default.
• W2067682358 hasPublicationYear "2011" @default.
• W2067682358 type Work @default.
• W2067682358 sameAs 2067682358 @default.
• W2067682358 citedByCount "34" @default.
• W2067682358 countsByYear W20676823582013 @default.
• W2067682358 countsByYear W20676823582014 @default.
• W2067682358 countsByYear W20676823582015 @default.
• W2067682358 countsByYear W20676823582016 @default.
• W2067682358 countsByYear W20676823582017 @default.
• W2067682358 countsByYear W20676823582018 @default.
• W2067682358 countsByYear W20676823582019 @default.
• W2067682358 countsByYear W20676823582020 @default.
• W2067682358 countsByYear W20676823582021 @default.
• W2067682358 countsByYear W20676823582022 @default.
• W2067682358 countsByYear W20676823582023 @default.
• W2067682358 crossrefType "journal-article" @default.
• W2067682358 hasAuthorship W2067682358A5048042845 @default.
• W2067682358 hasBestOaLocation W20676823581 @default.
• W2067682358 hasConcept C104317684 @default.
• W2067682358 hasConcept C14036430 @default.
• W2067682358 hasConcept C150194340 @default.
• W2067682358 hasConcept C165864922 @default.
• W2067682358 hasConcept C199360897 @default.
• W2067682358 hasConcept C41008148 @default.
• W2067682358 hasConcept C54355233 @default.
• W2067682358 hasConcept C86803240 @default.
• W2067682358 hasConcept C90559484 @default.
• W2067682358 hasConceptScore W2067682358C104317684 @default.
• W2067682358 hasConceptScore W2067682358C14036430 @default.
• W2067682358 hasConceptScore W2067682358C150194340 @default.
• W2067682358 hasConceptScore W2067682358C165864922 @default.
• W2067682358 hasConceptScore W2067682358C199360897 @default.
• W2067682358 hasConceptScore W2067682358C41008148 @default.
• W2067682358 hasConceptScore W2067682358C54355233 @default.
• W2067682358 hasConceptScore W2067682358C86803240 @default.
• W2067682358 hasConceptScore W2067682358C90559484 @default.
• W2067682358 hasIssue "11" @default.
• W2067682358 hasLocation W20676823581 @default.

• next