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• W2067687461 endingPage "14767" @default.
• W2067687461 startingPage "14761" @default.
• W2067687461 abstract "A new lanthanide chelating tag (M8) for paramagnetic labeling of biomolecules is presented, which is based on an eight-fold, stereoselectively methyl-substituted DOTA that can be covalently linked to the host molecule by a single disulfide bond. The steric overcrowding of the DOTA scaffold leads to an extremely rigid, kinetically and chemically inert lanthanide chelator. Its steric bulk restricts the motion of the tag relative to the host molecule. These properties result in very large pseudocontact shifts (>5 ppm) and residual dipolar couplings (>20 Hz) for Dy-M8 linked to ubiquitin, which are unprecedented for a small, single-point-attachment tag. Such large pseudocontact shifts should be well detectable even for larger proteins and distances beyond ∼50 Å. Due to its exceptionally high stability and lanthanide affinity M8 can be used under extreme chemical or physical conditions, such as those applied for protein denaturation, or when it is undesirable that buffer or protein react with excess lanthanide ions." @default.
• W2067687461 created "2016-06-24" @default.
• W2067687461 creator A5067405307 @default.
• W2067687461 creator A5079674718 @default.
• W2067687461 creator A5086718813 @default.
• W2067687461 date "2009-09-28" @default.
• W2067687461 modified "2023-10-01" @default.
• W2067687461 title "DOTA-M8: An Extremely Rigid, High-Affinity Lanthanide Chelating Tag for PCS NMR Spectroscopy" @default.
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• W2067687461 doi "https://doi.org/10.1021/ja903233w" @default.
• W2067687461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19785413" @default.
• W2067687461 hasPublicationYear "2009" @default.
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