Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067687552> ?p ?o ?g. }
- W2067687552 endingPage "e515" @default.
- W2067687552 startingPage "e515" @default.
- W2067687552 abstract "Prenatal maternal stress (PNMS) can impact a variety of outcomes in the offspring throughout childhood and persisting into adulthood as shown in human and animal studies. Many of the effects of PNMS on offspring outcomes likely reflect the effects of epigenetic changes, such as DNA methylation, to the fetal genome. However, no animal or human research can determine the extent to which the effects of PNMS on DNA methylation in human offspring is the result of the objective severity of the stressor to the pregnant mother, or her negative appraisal of the stressor or her resulting degree of negative stress. We examined the genome-wide DNA methylation profile in T cells from 34 adolescents whose mothers had rated the 1998 Québec ice storm’s consequences as positive or negative (that is, cognitive appraisal). The methylation levels of 2872 CGs differed significantly between adolescents in the positive and negative maternal cognitive appraisal groups. These CGs are affiliated with 1564 different genes and with 408 different biological pathways, which are prominently featured in immune function. Importantly, there was a significant overlap in the differentially methylated CGs or genes and biological pathways that are associated with cognitive appraisal and those associated with objective PNMS as we reported previously. Our study suggests that pregnant women’s cognitive appraisals of an independent stressor may have widespread effects on DNA methylation across the entire genome of their unborn children, detectable during adolescence. Therefore, cognitive appraisals could be an important predictor variable to explore in PNMS research." @default.
- W2067687552 created "2016-06-24" @default.
- W2067687552 creator A5007458839 @default.
- W2067687552 creator A5020485486 @default.
- W2067687552 creator A5043818350 @default.
- W2067687552 creator A5057582604 @default.
- W2067687552 creator A5081515888 @default.
- W2067687552 creator A5083063268 @default.
- W2067687552 date "2015-02-24" @default.
- W2067687552 modified "2023-10-14" @default.
- W2067687552 title "Pregnant women’s cognitive appraisal of a natural disaster affects DNA methylation in their children 13 years later: Project Ice Storm" @default.
- W2067687552 cites W137770119 @default.
- W2067687552 cites W1529920345 @default.
- W2067687552 cites W1967832563 @default.
- W2067687552 cites W1976062681 @default.
- W2067687552 cites W1984572170 @default.
- W2067687552 cites W1987071871 @default.
- W2067687552 cites W1987261032 @default.
- W2067687552 cites W2009878480 @default.
- W2067687552 cites W2016581631 @default.
- W2067687552 cites W2028971873 @default.
- W2067687552 cites W2034511686 @default.
- W2067687552 cites W2036904443 @default.
- W2067687552 cites W2039055473 @default.
- W2067687552 cites W2039282773 @default.
- W2067687552 cites W2039621927 @default.
- W2067687552 cites W2043583999 @default.
- W2067687552 cites W2047139732 @default.
- W2067687552 cites W2059631538 @default.
- W2067687552 cites W2067188132 @default.
- W2067687552 cites W2067455620 @default.
- W2067687552 cites W2080011484 @default.
- W2067687552 cites W2085185576 @default.
- W2067687552 cites W2085395274 @default.
- W2067687552 cites W2094530958 @default.
- W2067687552 cites W2100519604 @default.
- W2067687552 cites W2102655411 @default.
- W2067687552 cites W2102926673 @default.
- W2067687552 cites W2104471815 @default.
- W2067687552 cites W2109273085 @default.
- W2067687552 cites W2109934609 @default.
- W2067687552 cites W2110246809 @default.
- W2067687552 cites W2117679417 @default.
- W2067687552 cites W2118374327 @default.
- W2067687552 cites W2127489014 @default.
- W2067687552 cites W2134555825 @default.
- W2067687552 cites W2138288560 @default.
- W2067687552 cites W2139258084 @default.
- W2067687552 cites W2147026529 @default.
- W2067687552 cites W2151396264 @default.
- W2067687552 cites W2158060077 @default.
- W2067687552 cites W2163335252 @default.
- W2067687552 doi "https://doi.org/10.1038/tp.2015.13" @default.
- W2067687552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4445750" @default.
- W2067687552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25710121" @default.
- W2067687552 hasPublicationYear "2015" @default.
- W2067687552 type Work @default.
- W2067687552 sameAs 2067687552 @default.
- W2067687552 citedByCount "81" @default.
- W2067687552 countsByYear W20676875522015 @default.
- W2067687552 countsByYear W20676875522016 @default.
- W2067687552 countsByYear W20676875522017 @default.
- W2067687552 countsByYear W20676875522018 @default.
- W2067687552 countsByYear W20676875522019 @default.
- W2067687552 countsByYear W20676875522020 @default.
- W2067687552 countsByYear W20676875522021 @default.
- W2067687552 countsByYear W20676875522022 @default.
- W2067687552 countsByYear W20676875522023 @default.
- W2067687552 crossrefType "journal-article" @default.
- W2067687552 hasAuthorship W2067687552A5007458839 @default.
- W2067687552 hasAuthorship W2067687552A5020485486 @default.
- W2067687552 hasAuthorship W2067687552A5043818350 @default.
- W2067687552 hasAuthorship W2067687552A5057582604 @default.
- W2067687552 hasAuthorship W2067687552A5081515888 @default.
- W2067687552 hasAuthorship W2067687552A5083063268 @default.
- W2067687552 hasBestOaLocation W20676875521 @default.
- W2067687552 hasConcept C104317684 @default.
- W2067687552 hasConcept C112672928 @default.
- W2067687552 hasConcept C118552586 @default.
- W2067687552 hasConcept C125370674 @default.
- W2067687552 hasConcept C138496976 @default.
- W2067687552 hasConcept C150194340 @default.
- W2067687552 hasConcept C15744967 @default.
- W2067687552 hasConcept C169900460 @default.
- W2067687552 hasConcept C190727270 @default.
- W2067687552 hasConcept C2778119494 @default.
- W2067687552 hasConcept C2779234561 @default.
- W2067687552 hasConcept C33288867 @default.
- W2067687552 hasConcept C41091548 @default.
- W2067687552 hasConcept C42407357 @default.
- W2067687552 hasConcept C54355233 @default.
- W2067687552 hasConcept C70410870 @default.
- W2067687552 hasConcept C86803240 @default.
- W2067687552 hasConceptScore W2067687552C104317684 @default.
- W2067687552 hasConceptScore W2067687552C112672928 @default.
- W2067687552 hasConceptScore W2067687552C118552586 @default.
- W2067687552 hasConceptScore W2067687552C125370674 @default.
- W2067687552 hasConceptScore W2067687552C138496976 @default.