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- W2067688951 abstract "Autophagy, an evolutionarily conserved lysosomal degradation process, has drawn an increasing amount of attention in recent years for its role in a variety of human diseases, such as cancer. Notably, autophagy plays an important role in regulating several survival and death signaling pathways that determine cell fate in cancer. To date, substantial evidence has demonstrated that some key autophagic mediators, such as autophagy-related genes (ATGs), PI3K, mTOR, p53, and Beclin-1, may play crucial roles in modulating autophagic activity in cancer initiation and progression. Because autophagy-modulating agents such as rapamycin and chloroquine have already been used clinically to treat cancer, it is conceivable that targeting autophagic pathways may provide a new opportunity for discovery and development of more novel cancer therapeutics. With a deeper understanding of the regulatory mechanisms governing autophagy, we will have a better opportunity to facilitate the exploitation of autophagy as a target for therapeutic intervention in cancer. This review discusses the current status of targeting autophagic pathways as a potential cancer therapy." @default.
- W2067688951 created "2016-06-24" @default.
- W2067688951 creator A5036970153 @default.
- W2067688951 creator A5076066661 @default.
- W2067688951 creator A5078674610 @default.
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- W2067688951 date "2013-03-05" @default.
- W2067688951 modified "2023-09-27" @default.
- W2067688951 title "Targeting autophagic pathways for cancer drug discovery" @default.
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- W2067688951 doi "https://doi.org/10.5732/cjc.012.10010" @default.
- W2067688951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3845592" @default.
- W2067688951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22835386" @default.
- W2067688951 hasPublicationYear "2013" @default.
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