FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067701134> ?p ?o ?g. }

• W2067701134 abstract "The success of peripheral vein grafts is limited by intimal hyperplasia. Transforming growth factor (TGF)-beta(1) has effects on cell proliferation, apoptosis and extracellular matrix synthesis. We have previously observed positive changes in vessel healing with antisense to TGF-beta(1).Adenovirus was used to transduce rat femoral artery vein grafts with antisense to TGF-beta(1) (Ad-AST) or the sequence encoding the bioactive form of TGF-beta(1) (Ad-BAT). Grafts were harvested at 1, 2, 4 and 12 weeks and formalin fixed for immunohistochemical studies of the cell markers proliferating cellular nuclear antigen (proliferation) and active caspase 3 (apoptosis). In situ DNA fragmentation assays were also performed to confirm active caspase 3 results.Ad-AST treatment significantly (p = 0.05) increased apoptosis of macrophages inside the internal elastic lamina. In addition, Ad-AST treatment significantly increased the cellularity of the graft at early time points and reduced it at later time points (p = 0.01).The low levels of TGF-beta(1) in Ad-AST treatment promote apoptosis of macrophages and provide an environment that is more conducive to the proliferation or infiltration of cells that contribute to healthy vessels." @default.
• W2067701134 created "2016-06-24" @default.
• W2067701134 creator A5012264734 @default.
• W2067701134 creator A5048151471 @default.
• W2067701134 creator A5064828779 @default.
• W2067701134 creator A5082825343 @default.
• W2067701134 creator A5088635516 @default.
• W2067701134 date "2008-01-01" @default.
• W2067701134 modified "2023-09-27" @default.
• W2067701134 title "Antisense to Transforming Growth Factor-β₁ Facilitates the Apoptosis of Macrophages in Rat Vein Grafts" @default.
• W2067701134 cites W1505978562 @default.
• W2067701134 cites W1520988136 @default.
• W2067701134 cites W1972582706 @default.
• W2067701134 cites W1981505431 @default.
• W2067701134 cites W1993599412 @default.
• W2067701134 cites W1996126373 @default.
• W2067701134 cites W2008498256 @default.
• W2067701134 cites W2017946623 @default.
• W2067701134 cites W2025781946 @default.
• W2067701134 cites W2047822962 @default.
• W2067701134 cites W2059485506 @default.
• W2067701134 cites W2062199188 @default.
• W2067701134 cites W2063599136 @default.
• W2067701134 cites W2075181613 @default.
• W2067701134 cites W2077833316 @default.
• W2067701134 cites W2078043377 @default.
• W2067701134 cites W2085713110 @default.
• W2067701134 cites W2091931082 @default.
• W2067701134 cites W2098091709 @default.
• W2067701134 cites W2105227474 @default.
• W2067701134 cites W2107359871 @default.
• W2067701134 cites W2121822802 @default.
• W2067701134 cites W2122808924 @default.
• W2067701134 cites W2129703068 @default.
• W2067701134 cites W2137159939 @default.
• W2067701134 cites W2137285092 @default.
• W2067701134 cites W2154554320 @default.
• W2067701134 cites W2164293882 @default.
• W2067701134 cites W2166797660 @default.
• W2067701134 cites W2168915058 @default.
• W2067701134 cites W2221989160 @default.
• W2067701134 doi "https://doi.org/10.1159/000121406" @default.
• W2067701134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18354256" @default.
• W2067701134 hasPublicationYear "2008" @default.
• W2067701134 type Work @default.
• W2067701134 sameAs 2067701134 @default.
• W2067701134 citedByCount "4" @default.
• W2067701134 countsByYear W20677011342014 @default.
• W2067701134 countsByYear W20677011342016 @default.
• W2067701134 countsByYear W20677011342017 @default.
• W2067701134 crossrefType "journal-article" @default.
• W2067701134 hasAuthorship W2067701134A5012264734 @default.
• W2067701134 hasAuthorship W2067701134A5048151471 @default.
• W2067701134 hasAuthorship W2067701134A5064828779 @default.
• W2067701134 hasAuthorship W2067701134A5082825343 @default.
• W2067701134 hasAuthorship W2067701134A5088635516 @default.
• W2067701134 hasConcept C105702510 @default.
• W2067701134 hasConcept C118131993 @default.
• W2067701134 hasConcept C126322002 @default.
• W2067701134 hasConcept C142724271 @default.
• W2067701134 hasConcept C170493617 @default.
• W2067701134 hasConcept C185592680 @default.
• W2067701134 hasConcept C190283241 @default.
• W2067701134 hasConcept C202751555 @default.
• W2067701134 hasConcept C2775960820 @default.
• W2067701134 hasConcept C2777202286 @default.
• W2067701134 hasConcept C2779244956 @default.
• W2067701134 hasConcept C55493867 @default.
• W2067701134 hasConcept C71924100 @default.
• W2067701134 hasConcept C86803240 @default.
• W2067701134 hasConcept C95444343 @default.
• W2067701134 hasConceptScore W2067701134C105702510 @default.
• W2067701134 hasConceptScore W2067701134C118131993 @default.
• W2067701134 hasConceptScore W2067701134C126322002 @default.
• W2067701134 hasConceptScore W2067701134C142724271 @default.
• W2067701134 hasConceptScore W2067701134C170493617 @default.
• W2067701134 hasConceptScore W2067701134C185592680 @default.
• W2067701134 hasConceptScore W2067701134C190283241 @default.
• W2067701134 hasConceptScore W2067701134C202751555 @default.
• W2067701134 hasConceptScore W2067701134C2775960820 @default.
• W2067701134 hasConceptScore W2067701134C2777202286 @default.
• W2067701134 hasConceptScore W2067701134C2779244956 @default.
• W2067701134 hasConceptScore W2067701134C55493867 @default.
• W2067701134 hasConceptScore W2067701134C71924100 @default.
• W2067701134 hasConceptScore W2067701134C86803240 @default.
• W2067701134 hasConceptScore W2067701134C95444343 @default.
• W2067701134 hasLocation W20677011341 @default.
• W2067701134 hasLocation W20677011342 @default.
• W2067701134 hasOpenAccess W2067701134 @default.
• W2067701134 hasPrimaryLocation W20677011341 @default.
• W2067701134 hasRelatedWork W1965225122 @default.
• W2067701134 hasRelatedWork W1975250411 @default.
• W2067701134 hasRelatedWork W1989670744 @default.
• W2067701134 hasRelatedWork W1992427960 @default.
• W2067701134 hasRelatedWork W2003089081 @default.
• W2067701134 hasRelatedWork W2005786175 @default.
• W2067701134 hasRelatedWork W2017813592 @default.
• W2067701134 hasRelatedWork W2038336983 @default.
• W2067701134 hasRelatedWork W2040490980 @default.
• W2067701134 hasRelatedWork W2043180135 @default.

• next