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• W2067701349 abstract "1. The physiological and pharmacological actions of noradrenaline (NA) on neurons of the medial septum and diagonal band of Broca (MSDB) were examined using extracellular, intracellular and whole-cell patch-clamp recordings in an in vitro rat brain slice preparation. 2. In current- and voltage-clamp recordings with KCl- or potassium gluconate-containing electrodes, bath-applied NA increased the number of tetrodoxin- and bicuculline-sensitive synaptic events in > 80% of cholinergic- and GABA-type neurons tested. The NA-induced synaptic activity originated from GABAergic neurons located within the MSDB itself, as a similar effect occurred in brain slices in which the MSDB had been surgically isolated from neighbouring structures. 3. In antidromic studies, NA dose-dependently increased firing in a subpopulation of septohippocampal neurons with fast conducting fibres (mean conduction velocity, 1.78 +/- 0.10 m s-1; presumably GABAergic). The NA excitation was mimicked by the alpha 1-agonist phenylephrine (PE) and blocked by the alpha 1-antagonists prazosin and WB-4101, suggesting the presence of alpha 1-receptors on septohippocampal GABAergic neurons. 4. Similarly, in whole-cell recordings in both cholinergic- and non-cholinergic-type MSDB neurons, prazosin blocked the effects of NA and PE mimicked the effects of NA by inducing IPSCs with a similar amplitude distribution. 5. Consistent with the above findings, GABA-type neurons that responded directly to NA and PE with a prazosin-sensitive inward current were found within the MSDB. 6. In conclusion, NA, via alpha 1-adrenoceptors, excites MSDB septohippocampal GABAergic neurons and influences both septal and septohippocampal circuitry." @default.
• W2067701349 created "2016-06-24" @default.
• W2067701349 creator A5039124639 @default.
• W2067701349 creator A5041183259 @default.
• W2067701349 date "1996-07-01" @default.
• W2067701349 modified "2023-09-24" @default.
• W2067701349 title "Noradrenaline induces IPSCs in rat medial septal/diagonal band neurons: involvement of septohippocampal GABAergic neurons." @default.
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• W2067701349 doi "https://doi.org/10.1113/jphysiol.1996.sp021485" @default.
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