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• W2067701357 endingPage "e33091" @default.
• W2067701357 startingPage "e33091" @default.
• W2067701357 abstract "The marine mussel Mytilus edulis and its closely related sister species are distributed world-wide and play an important role in coastal ecology and economy. The diversification in different species and their hybrids, broad ecological distribution, as well as the filter feeding mode of life has made this genus an attractive model to investigate physiological and molecular adaptations and responses to various biotic and abiotic environmental factors. In the present study we investigated the immune system of Mytilus, which may contribute to the ecological plasticity of this species. We generated a large Mytilus transcriptome database from different tissues of immune challenged and stress treated individuals from the Baltic Sea using 454 pyrosequencing. Phylogenetic comparison of orthologous groups of 23 species demonstrated the basal position of lophotrochozoans within protostomes. The investigation of immune related transcripts revealed a complex repertoire of innate recognition receptors and downstream pathway members including transcripts for 27 toll-like receptors and 524 C1q domain containing transcripts. NOD-like receptors on the other hand were absent. We also found evidence for sophisticated TNF, autophagy and apoptosis systems as well as for cytokines. Gill tissue and hemocytes showed highest expression of putative immune related contigs and are promising tissues for further functional studies. Our results partly contrast with findings of a less complex immune repertoire in ecdysozoan and other lophotrochozoan protostomes. We show that bivalves are interesting candidates to investigate the evolution of the immune system from basal metazoans to deuterostomes and protostomes and provide a basis for future molecular work directed to immune system functioning in Mytilus." @default.
• W2067701357 created "2016-06-24" @default.
• W2067701357 creator A5007743755 @default.
• W2067701357 creator A5023656983 @default.
• W2067701357 creator A5054564152 @default.
• W2067701357 creator A5059435501 @default.
• W2067701357 creator A5068429817 @default.
• W2067701357 creator A5072621606 @default.
• W2067701357 creator A5084409898 @default.
• W2067701357 creator A5089518171 @default.
• W2067701357 date "2012-03-20" @default.
• W2067701357 modified "2023-10-08" @default.
• W2067701357 title "Massively Parallel RNA Sequencing Identifies a Complex Immune Gene Repertoire in the lophotrochozoan Mytilus edulis" @default.
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