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- W2067701691 abstract "A previous report of a novel pneumovirus (PnV) isolated from the respiratory tract of a dog described its significant homology to the rodent pathogen, pneumonia virus of mice (PVM). The original PnV–Ane4 pathogen replicated in and could be re-isolated in infectious state from mouse lung but elicited minimal mortality compared to PVM strain J3666. Here we assess phylogeny and physiologic responses to 10 new PnV isolates. The G/glycoprotein sequences of all PnVs include elongated amino-termini when compared to the characterized PVMs, and suggest division into groups A and B. While we observed significant differences in cytokine production and neutrophil recruitment to the lungs of BALB/c mice in response to survival doses (50 TCID50 units) of representative group A (114378-10-29-KY-F) and group B (7968-11-OK) PnVs, we observed no evidence for positive selection (dN>dS) among the PnV/PnV, PVM/PnV or PVM/PVM G/glycoprotein or F/fusion protein sequence pairs." @default.
- W2067701691 created "2016-06-24" @default.
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- W2067701691 date "2013-09-01" @default.
- W2067701691 modified "2023-10-03" @default.
- W2067701691 title "Novel pneumoviruses (PnVs): Evolution and inflammatory pathology" @default.
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- W2067701691 doi "https://doi.org/10.1016/j.virol.2013.05.011" @default.
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