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• W2067719679 abstract "SUMMARY Infection of intermediate hosts with eggs of taeniid parasites results in a larval infestation known as cysticercosis. A number of studies have indicated that cysticercosis is associated with immunosuppression, although little is known about the mechanisms involved. In the present study, mice infected with the larvae of Taenia crassiceps were found to exhibit a pronounced anergy, which preferentially affected T-cells located anatomically close to the parasite. This anergy was linked to late events in the T cell activation pathway; that is, stimulation through the T cell receptor(TCR)/CD complex by Concanavalin-A, or plate-bound monoclonal antibodies (mAb) to TCRαβ or CD3ε, or combinations of phorbol ester and ionomycin (all of which can bypass early membrane-related events), failed to fully activate T lymphocytes. The relative proximity of T cells to the parasite was directly related to upregulation of IL-4 and downregulation of IL-2 production. In addition, the profiles of parasite-specific Abs showed an exclusive increase of serum IgG1 during infection. Taken together, the data suggest that infection of mice with larvae of T. crassiceps alters the balance of CD4 + Th cells by upregulating Th2 and downregulating Th1 cells located in close proximity to the parasite." @default.
• W2067719679 created "2016-06-24" @default.
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• W2067719679 date "1996-06-01" @default.
• W2067719679 modified "2023-10-14" @default.
• W2067719679 title "Mice infected with the larvae of<i>Taenia crassiceps</i>exhibit a Th2-like immune response with concomitant anergy and downregulation of Th1-associated phenomena" @default.
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• W2067719679 doi "https://doi.org/10.1017/s0031182000066142" @default.
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