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- W2067734461 abstract "Pretreatment of Chinese hamster ovary (CHO) or H4 (rat hepatoma) cells with low non-toxic doses of H2O2 or xanthine-xanthine oxidase renders the cells more resistant to the toxic effect of H2O2 and γ-rays. This increased resistance is observed both in exponentially growing and in plateau-phase cells. Cells pretreated with xanthine-xanthine oxidase are less mutated than control cultures when challenged with ionizing radiation. The number of DNA single-strand breaks (measured by nucleoid sedimentation) induced by a high dose of γ-rays or H2O2 is lower in cells pretreated with xanthine-xanthine oxidase compared to control cultures. However, the pretreatment does not modify the rate of DNA single-strand breaks rejoining in cells challenged with H2O2 or γ-rays. The catalase activity is not modified in pretreated cells, but the superoxide dismutase activity is increased about 2-fold." @default.
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- W2067734461 date "1988-09-01" @default.
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- W2067734461 title "Pretreatment with oxygen species increases the resistance of mammalian cells to hydrogen peroxide and γ-rays" @default.
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- W2067734461 doi "https://doi.org/10.1016/0027-5107(88)90112-1" @default.
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