FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067740392> ?p ?o ?g. }

• W2067740392 endingPage "19293" @default.
• W2067740392 startingPage "19284" @default.
• W2067740392 abstract "Borrelia burgdorferi, the causative agent of Lyme disease, exists in nature through a complex life cycle involving ticks of the Ixodes genus and mammalian hosts. During its life cycle, B. burgdorferi experiences fluctuations in oxygen tension and may encounter reactive oxygen species (ROS). The key metalloenzyme to degrade ROS in B. burgdorferi is SodA. Although previous work suggests that B. burgdorferi SodA is an iron-dependent superoxide dismutase (SOD), later work demonstrates that B. burgdorferi is unable to transport iron and contains an extremely low intracellular concentration of iron. Consequently, the metal cofactor for SodA has been postulated to be manganese. However, experimental evidence to support this hypothesis remains lacking. In this study, we provide biochemical and genetic data showing that SodA is a manganese-dependent enzyme. First, B. burgdorferi contained SOD activity that is resistant to H(2)O(2) and NaCN, characteristics associated with Mn-SODs. Second, the addition of manganese to the Chelex-treated BSK-II enhanced SodA expression. Third, disruption of the manganese transporter gene bmtA, which significantly lowers the intracellular manganese, greatly reduced SOD activity and SodA expression, suggesting that manganese regulates the level of SodA. In addition, we show that B. burgdorferi is resistant to streptonigrin, a metal-dependent redox cycling compound that produces ROS, and that SodA plays a protective role against the streptonigrin. Taken together, our data demonstrate the Lyme disease spirochete encodes a manganese-dependent SOD that contributes to B. burgdorferi defense against intracellular superoxide." @default.
• W2067740392 created "2016-06-24" @default.
• W2067740392 creator A5029810331 @default.
• W2067740392 creator A5030300255 @default.
• W2067740392 creator A5060809525 @default.
• W2067740392 date "2012-06-01" @default.
• W2067740392 modified "2023-09-29" @default.
• W2067740392 title "Borrelia burgdorferi, a Pathogen That Lacks Iron, Encodes Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin" @default.
• W2067740392 cites W1491877983 @default.
• W2067740392 cites W1509038183 @default.
• W2067740392 cites W1514186391 @default.
• W2067740392 cites W1516318762 @default.
• W2067740392 cites W1533514289 @default.
• W2067740392 cites W1558162435 @default.
• W2067740392 cites W1559583668 @default.
• W2067740392 cites W1563643953 @default.
• W2067740392 cites W1571922788 @default.
• W2067740392 cites W1576106895 @default.
• W2067740392 cites W1583063946 @default.
• W2067740392 cites W1589359602 @default.
• W2067740392 cites W1590251223 @default.
• W2067740392 cites W1605373773 @default.
• W2067740392 cites W1635484747 @default.
• W2067740392 cites W1668155437 @default.
• W2067740392 cites W1816687768 @default.
• W2067740392 cites W1926303070 @default.
• W2067740392 cites W1940436875 @default.
• W2067740392 cites W1964795596 @default.
• W2067740392 cites W1969762827 @default.
• W2067740392 cites W1982548251 @default.
• W2067740392 cites W1983604618 @default.
• W2067740392 cites W1990000387 @default.
• W2067740392 cites W1991588702 @default.
• W2067740392 cites W1998642689 @default.
• W2067740392 cites W2007296377 @default.
• W2067740392 cites W2010016694 @default.
• W2067740392 cites W2013636685 @default.
• W2067740392 cites W2035273924 @default.
• W2067740392 cites W2035678345 @default.
• W2067740392 cites W2042968475 @default.
• W2067740392 cites W2051930365 @default.
• W2067740392 cites W2056919365 @default.
• W2067740392 cites W2063367477 @default.
• W2067740392 cites W2068935039 @default.
• W2067740392 cites W2076315300 @default.
• W2067740392 cites W2084975317 @default.
• W2067740392 cites W2098046516 @default.
• W2067740392 cites W2101422765 @default.
• W2067740392 cites W2104470997 @default.
• W2067740392 cites W2105281406 @default.
• W2067740392 cites W2111328511 @default.
• W2067740392 cites W2111485154 @default.
• W2067740392 cites W2116177758 @default.
• W2067740392 cites W2120349315 @default.
• W2067740392 cites W2121726441 @default.
• W2067740392 cites W2123757128 @default.
• W2067740392 cites W2131492700 @default.
• W2067740392 cites W2142449740 @default.
• W2067740392 cites W2144624675 @default.
• W2067740392 cites W2154970061 @default.
• W2067740392 cites W2159714389 @default.
• W2067740392 cites W2162264591 @default.
• W2067740392 cites W2171617406 @default.
• W2067740392 cites W2301392926 @default.
• W2067740392 cites W98700330 @default.
• W2067740392 doi "https://doi.org/10.1074/jbc.m112.344903" @default.
• W2067740392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3365960" @default.
• W2067740392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22500025" @default.
• W2067740392 hasPublicationYear "2012" @default.
• W2067740392 type Work @default.
• W2067740392 sameAs 2067740392 @default.
• W2067740392 citedByCount "53" @default.
• W2067740392 countsByYear W20677403922012 @default.
• W2067740392 countsByYear W20677403922013 @default.
• W2067740392 countsByYear W20677403922014 @default.
• W2067740392 countsByYear W20677403922015 @default.
• W2067740392 countsByYear W20677403922016 @default.
• W2067740392 countsByYear W20677403922017 @default.
• W2067740392 countsByYear W20677403922018 @default.
• W2067740392 countsByYear W20677403922019 @default.
• W2067740392 countsByYear W20677403922020 @default.
• W2067740392 countsByYear W20677403922021 @default.
• W2067740392 countsByYear W20677403922022 @default.
• W2067740392 countsByYear W20677403922023 @default.
• W2067740392 crossrefType "journal-article" @default.
• W2067740392 hasAuthorship W2067740392A5029810331 @default.
• W2067740392 hasAuthorship W2067740392A5030300255 @default.
• W2067740392 hasAuthorship W2067740392A5060809525 @default.
• W2067740392 hasBestOaLocation W20677403921 @default.
• W2067740392 hasConcept C159654299 @default.
• W2067740392 hasConcept C178790620 @default.
• W2067740392 hasConcept C185592680 @default.
• W2067740392 hasConcept C2775838275 @default.
• W2067740392 hasConcept C2776151105 @default.
• W2067740392 hasConcept C2776460866 @default.
• W2067740392 hasConcept C2778248901 @default.
• W2067740392 hasConcept C2779159148 @default.
• W2067740392 hasConcept C48349386 @default.

• next