Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067743669> ?p ?o ?g. }
- W2067743669 endingPage "910" @default.
- W2067743669 startingPage "904" @default.
- W2067743669 abstract "<h3>Objectives:</h3> Experiments in animal models have identified specific subcortical anatomic circuits, which are critically involved in the pathogenesis and control of seizure activity. However, whether such anatomic substrates also exist in human epilepsy is not known. <h3>Methods:</h3> We studied 2 separate groups of patients with focal epilepsies arising from any cortical location using either simultaneous EEG-fMRI (n = 19 patients) or [<sup>11</sup>C]flumazenil PET (n = 18). <h3>Results:</h3> Time-locked with the interictal epileptiform discharges, we found significant hemodynamic increases common to all patients near the frontal piriform cortex ipsilateral to the presumed cortical focus. GABA<sub>A</sub> receptor binding in the same area was reduced in patients with more frequent seizures. <h3>Conclusions:</h3> Our findings of cerebral blood flow and GABAergic changes, irrespective of where interictal or ictal activity occurs in the cortex, suggest that this area of the human primary olfactory cortex may be an attractive new target for epilepsy therapy, including neurosurgery, electrical stimulation, and focal drug delivery." @default.
- W2067743669 created "2016-06-24" @default.
- W2067743669 creator A5002881267 @default.
- W2067743669 creator A5007219011 @default.
- W2067743669 creator A5010235451 @default.
- W2067743669 creator A5036003335 @default.
- W2067743669 creator A5041903309 @default.
- W2067743669 creator A5059608304 @default.
- W2067743669 creator A5062693974 @default.
- W2067743669 creator A5069016381 @default.
- W2067743669 creator A5083210265 @default.
- W2067743669 date "2011-08-17" @default.
- W2067743669 modified "2023-09-25" @default.
- W2067743669 title "Converging PET and fMRI evidence for a common area involved in human focal epilepsies" @default.
- W2067743669 cites W1480770914 @default.
- W2067743669 cites W1977813492 @default.
- W2067743669 cites W1978097744 @default.
- W2067743669 cites W1986025484 @default.
- W2067743669 cites W1995492219 @default.
- W2067743669 cites W1995908151 @default.
- W2067743669 cites W2002608596 @default.
- W2067743669 cites W2005238835 @default.
- W2067743669 cites W2009253761 @default.
- W2067743669 cites W2010775703 @default.
- W2067743669 cites W2022907828 @default.
- W2067743669 cites W2026433590 @default.
- W2067743669 cites W2031669175 @default.
- W2067743669 cites W2033829782 @default.
- W2067743669 cites W2035837210 @default.
- W2067743669 cites W2039236424 @default.
- W2067743669 cites W2049356275 @default.
- W2067743669 cites W2065750154 @default.
- W2067743669 cites W2069328624 @default.
- W2067743669 cites W2071928207 @default.
- W2067743669 cites W2079725109 @default.
- W2067743669 cites W2099478180 @default.
- W2067743669 cites W2101067729 @default.
- W2067743669 cites W2113889563 @default.
- W2067743669 cites W2117879450 @default.
- W2067743669 cites W2120745993 @default.
- W2067743669 cites W2124839923 @default.
- W2067743669 cites W2132692319 @default.
- W2067743669 cites W2136709687 @default.
- W2067743669 cites W2136807926 @default.
- W2067743669 cites W2139503520 @default.
- W2067743669 cites W2150801980 @default.
- W2067743669 cites W2157020359 @default.
- W2067743669 cites W2169428430 @default.
- W2067743669 cites W2185218987 @default.
- W2067743669 cites W2399595378 @default.
- W2067743669 cites W2462318547 @default.
- W2067743669 cites W2581674416 @default.
- W2067743669 cites W2443203453 @default.
- W2067743669 doi "https://doi.org/10.1212/wnl.0b013e31822c90f2" @default.
- W2067743669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162638" @default.
- W2067743669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21849655" @default.
- W2067743669 hasPublicationYear "2011" @default.
- W2067743669 type Work @default.
- W2067743669 sameAs 2067743669 @default.
- W2067743669 citedByCount "98" @default.
- W2067743669 countsByYear W20677436692012 @default.
- W2067743669 countsByYear W20677436692013 @default.
- W2067743669 countsByYear W20677436692014 @default.
- W2067743669 countsByYear W20677436692015 @default.
- W2067743669 countsByYear W20677436692016 @default.
- W2067743669 countsByYear W20677436692017 @default.
- W2067743669 countsByYear W20677436692018 @default.
- W2067743669 countsByYear W20677436692019 @default.
- W2067743669 countsByYear W20677436692020 @default.
- W2067743669 countsByYear W20677436692021 @default.
- W2067743669 countsByYear W20677436692022 @default.
- W2067743669 countsByYear W20677436692023 @default.
- W2067743669 crossrefType "journal-article" @default.
- W2067743669 hasAuthorship W2067743669A5002881267 @default.
- W2067743669 hasAuthorship W2067743669A5007219011 @default.
- W2067743669 hasAuthorship W2067743669A5010235451 @default.
- W2067743669 hasAuthorship W2067743669A5036003335 @default.
- W2067743669 hasAuthorship W2067743669A5041903309 @default.
- W2067743669 hasAuthorship W2067743669A5059608304 @default.
- W2067743669 hasAuthorship W2067743669A5062693974 @default.
- W2067743669 hasAuthorship W2067743669A5069016381 @default.
- W2067743669 hasAuthorship W2067743669A5083210265 @default.
- W2067743669 hasBestOaLocation W20677436692 @default.
- W2067743669 hasConcept C15744967 @default.
- W2067743669 hasConcept C157767197 @default.
- W2067743669 hasConcept C169760540 @default.
- W2067743669 hasConcept C17077164 @default.
- W2067743669 hasConcept C17755696 @default.
- W2067743669 hasConcept C2777348757 @default.
- W2067743669 hasConcept C2777350023 @default.
- W2067743669 hasConcept C2777670902 @default.
- W2067743669 hasConcept C2778186239 @default.
- W2067743669 hasConcept C2778541695 @default.
- W2067743669 hasConcept C2779177108 @default.
- W2067743669 hasConcept C2780382662 @default.
- W2067743669 hasConcept C2781041448 @default.
- W2067743669 hasConcept C42219234 @default.
- W2067743669 hasConcept C522805319 @default.