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- W2067756803 abstract "An endogenous inhibitor(s) of [3H] diazepam binding to synaptosomes has been demonstrated in bovine brain. The inhibitory activity of crude extracts is heat stable, dialyzable, and not affected by ether extraction. Three distinct peaks of inhibitory activity were resolved using Sephadex G-25 chromatography. The lowest molecular weight peak (<700 daltons) had the highest specific inhibitory activity and its inhibition of [3H] diazepam binding was competitive. A similar low molecular weight fraction was not observed in either muscle or liver suggesting that it may be unique to brain. Thin layer chromatography of the Sephadex G-25 fractions revealed a discrete band of inhibitory activity in the two low molecular weight peaks." @default.
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- W2067756803 date "1978-06-01" @default.
- W2067756803 modified "2023-09-25" @default.
- W2067756803 title "Demonstration of an endogenous, competitive inhibitor(s) of [3H] diazepam binding in bovine brain" @default.
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- W2067756803 doi "https://doi.org/10.1016/0024-3205(78)90476-9" @default.
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