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- W2067759840 abstract "SUMMARY Canagliflozin is a competitive, reversible and potent inhibitor of SGLT2 that lowers the renal threshold for glucose and consequently increases urinary glucose excretion in people with Type 2 diabetes with a blood glucose level above 70–90 mg/dl. Its oral administration in daily doses of 100 and 300 mg in monotherapy, dual therapy or triple therapy including insulin produces a mean HbA1c reduction of 0.7 and 0.85%, respectively, when compared with placebo, a similar reduction to sitagliptin and glimepiride. There is also a modest reduction in weight with both doses. The main adverse effects are genital fungal infections, particularly in women, and, less frequently, urinary tract infections." @default.
- W2067759840 created "2016-06-24" @default.
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- W2067759840 date "2013-07-01" @default.
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- W2067759840 title "Canagliflozin for the treatment of adults with Type 2 diabetes" @default.
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- W2067759840 doi "https://doi.org/10.2217/dmt.13.23" @default.
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