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• W2067763603 abstract "1. In an attempt to determine the metabolic defect causing severe combined immunodeficiency (SCID) in horses in which altered purine metabolism has been observed, various parameters of purine and pyrimidine metabolism were evaluated. 2. The activities of nine purine enzymes (adenosine kinase, purine nucleoside phosphorylase, deoxyadenosine kinase, deoxycytidine kinase, 5′-nucleotidase, AMP deaminase, hypoxanthine-guanine phosphoribosyl transferase, and adenine phosphoribosyl transferase were measured in fibroblasts. All activities determined for SCID horses were normal. 3. Uptake of 10 μM adenosine or 2′-deoxyadenosine (a growth inhibitory concentration for SCID fibroblasts) by SCID fibroblasts was identical to that found for normal fibroblasts in the presence of both 1 and 50 μM phosphate. The Km determined for the transport of both adenosine and 2′-deoxyadenosine was 35 μM. 4. In the presence of p-nitrobenzylthioguanosine (a nucleoside transport inhibitor), 2′-deoxyadenosine uptake was inhibited to the same extent in all fibroblast lines tested. 5. To determine if the last step in pyrimidine biosynthesis might be altered in SCID fibroblasts, UMP synthase activities were evaluated but found to be normal (0.5 nmol UMP formed/min/mg protein)." @default.
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• W2067763603 date "1985-01-01" @default.
• W2067763603 modified "2023-09-27" @default.
• W2067763603 title "Metabolic investigations of fibroblasts from horses, Equus caballus, with hereditary severe combined immunodeficiency" @default.
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• W2067763603 doi "https://doi.org/10.1016/0305-0491(85)90405-5" @default.
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