Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067765150> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2067765150 endingPage "354" @default.
- W2067765150 startingPage "344" @default.
- W2067765150 abstract "The administration of appropriate doses of interferon to cultures of Friend leukemia cells causes a pronounced inhibition of cell growth. Several lines of evidence indicate that this effect is due to interferon itself, rather than to unknown contaminants of interferon preparations. Autoradiograph analysis of growth parameters of Friend leukemia cells during treatment with interferon demonstrates that the rate of entry into the S phase, the percent decline of unlabeled mitoses, and the mitotic indexes are significantly lower in interferon-treated cell cultures than in control untreated cultures when tritiated thymidine was added 12 h after the administration of interferon. These data indicate that fractions of interferon-treated cell population are delayed in both G1 and in G2 phases of the cell cycle. This was confirmed by exact measurements of the length of the various phases of the cycle. The interferon-induced inhibition of growth of Friend leukemia cells is reversible after removal of the compound. Autoradiograph data obtained from control cultures and from cultures previously treated with interferon that had been washed free of interferon and reseeded in interferon-free medium, demonstrate that during the first 12 h after removal of interferon, a large majority of the cells previously treated with interferon had a deranged flow into the S phase, a high number of unlabeled mitoses, and a low mitotic index. These data provide further evidence for the above-mentioned prolongations of G1 and G2 phases of the cell cycle. All growth parameters tested reverted to normal values within 12 h after washing out interferon." @default.
- W2067765150 created "2016-06-24" @default.
- W2067765150 creator A5032337055 @default.
- W2067765150 creator A5087874445 @default.
- W2067765150 date "1977-11-01" @default.
- W2067765150 modified "2023-09-27" @default.
- W2067765150 title "Effect of interferon on growth and division cycle of Friend erythroleukemic murine cells in vitro." @default.
- W2067765150 cites W1555094581 @default.
- W2067765150 cites W1921604066 @default.
- W2067765150 cites W1944607338 @default.
- W2067765150 cites W1964595610 @default.
- W2067765150 cites W1974182735 @default.
- W2067765150 cites W1979704489 @default.
- W2067765150 cites W1990838439 @default.
- W2067765150 cites W2006669071 @default.
- W2067765150 cites W2007847579 @default.
- W2067765150 cites W2047511510 @default.
- W2067765150 cites W2049675353 @default.
- W2067765150 cites W2066971317 @default.
- W2067765150 cites W2070297871 @default.
- W2067765150 cites W2087497229 @default.
- W2067765150 cites W2163585868 @default.
- W2067765150 cites W2265274228 @default.
- W2067765150 cites W2318565545 @default.
- W2067765150 cites W2319797826 @default.
- W2067765150 cites W2330420558 @default.
- W2067765150 cites W2412580131 @default.
- W2067765150 doi "https://doi.org/10.1083/jcb.75.2.344" @default.
- W2067765150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2109928" @default.
- W2067765150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/95668" @default.
- W2067765150 hasPublicationYear "1977" @default.
- W2067765150 type Work @default.
- W2067765150 sameAs 2067765150 @default.
- W2067765150 citedByCount "49" @default.
- W2067765150 crossrefType "journal-article" @default.
- W2067765150 hasAuthorship W2067765150A5032337055 @default.
- W2067765150 hasAuthorship W2067765150A5087874445 @default.
- W2067765150 hasBestOaLocation W20677651501 @default.
- W2067765150 hasConcept C1491633281 @default.
- W2067765150 hasConcept C153911025 @default.
- W2067765150 hasConcept C202751555 @default.
- W2067765150 hasConcept C203014093 @default.
- W2067765150 hasConcept C2776178377 @default.
- W2067765150 hasConcept C2777108182 @default.
- W2067765150 hasConcept C2778461978 @default.
- W2067765150 hasConcept C2781228144 @default.
- W2067765150 hasConcept C2909179924 @default.
- W2067765150 hasConcept C29537977 @default.
- W2067765150 hasConcept C54355233 @default.
- W2067765150 hasConcept C55493867 @default.
- W2067765150 hasConcept C66640590 @default.
- W2067765150 hasConcept C81885089 @default.
- W2067765150 hasConcept C85813293 @default.
- W2067765150 hasConcept C86803240 @default.
- W2067765150 hasConcept C93304396 @default.
- W2067765150 hasConcept C95444343 @default.
- W2067765150 hasConceptScore W2067765150C1491633281 @default.
- W2067765150 hasConceptScore W2067765150C153911025 @default.
- W2067765150 hasConceptScore W2067765150C202751555 @default.
- W2067765150 hasConceptScore W2067765150C203014093 @default.
- W2067765150 hasConceptScore W2067765150C2776178377 @default.
- W2067765150 hasConceptScore W2067765150C2777108182 @default.
- W2067765150 hasConceptScore W2067765150C2778461978 @default.
- W2067765150 hasConceptScore W2067765150C2781228144 @default.
- W2067765150 hasConceptScore W2067765150C2909179924 @default.
- W2067765150 hasConceptScore W2067765150C29537977 @default.
- W2067765150 hasConceptScore W2067765150C54355233 @default.
- W2067765150 hasConceptScore W2067765150C55493867 @default.
- W2067765150 hasConceptScore W2067765150C66640590 @default.
- W2067765150 hasConceptScore W2067765150C81885089 @default.
- W2067765150 hasConceptScore W2067765150C85813293 @default.
- W2067765150 hasConceptScore W2067765150C86803240 @default.
- W2067765150 hasConceptScore W2067765150C93304396 @default.
- W2067765150 hasConceptScore W2067765150C95444343 @default.
- W2067765150 hasIssue "2" @default.
- W2067765150 hasLocation W20677651501 @default.
- W2067765150 hasLocation W20677651502 @default.
- W2067765150 hasLocation W20677651503 @default.
- W2067765150 hasLocation W20677651504 @default.
- W2067765150 hasOpenAccess W2067765150 @default.
- W2067765150 hasPrimaryLocation W20677651501 @default.
- W2067765150 hasRelatedWork W1522240561 @default.
- W2067765150 hasRelatedWork W1964580116 @default.
- W2067765150 hasRelatedWork W1974281214 @default.
- W2067765150 hasRelatedWork W1980383744 @default.
- W2067765150 hasRelatedWork W2001774478 @default.
- W2067765150 hasRelatedWork W2070090536 @default.
- W2067765150 hasRelatedWork W2091252403 @default.
- W2067765150 hasRelatedWork W2102962755 @default.
- W2067765150 hasRelatedWork W2110600735 @default.
- W2067765150 hasRelatedWork W2157348220 @default.
- W2067765150 hasVolume "75" @default.
- W2067765150 isParatext "false" @default.
- W2067765150 isRetracted "false" @default.
- W2067765150 magId "2067765150" @default.
- W2067765150 workType "article" @default.