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- W2067783320 endingPage "621" @default.
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- W2067783320 abstract "Recent evidence indicates that the slowly expanding population of CD5+ B cells that characterizes chronic lymphocytic leukemia (CLL) results primarily from defects in responses to cytokines that regulate apoptosis (e.g. I1-4, TGF-beta, IFN-alpha, IFN-gamma). We have now demonstrated not only that the enhanced anti-apoptotic effect of IFN-gamma on these neoplastic B cells is apparently mediated through increased levels of IFN-gamma receptors but also that there are increased numbers of IFN-gamma-expressing CD4 and CD8 T cells in these patients. This is the strongest evidence to date that multiple alterations in the IFN-gamma cytokine network contribute to the pathogenesis of CLL." @default.
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- W2067783320 date "2000-07-01" @default.
- W2067783320 modified "2023-09-24" @default.
- W2067783320 title "Disruption of the IFN-γ cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis" @default.
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- W2067783320 doi "https://doi.org/10.1016/s0145-2126(00)00022-9" @default.
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