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- W2067785703 abstract "The diazonium salt of 5′-(4-aminophenyl phosphoryl)-uridine 2′(3′)-phosphate reacts stoichiometrically with pancreatic ribonuclease and modifies only one tyrosyl residue, which was identified as Tyr 73 in the amino acid sequence. The modification does not inhibit the biological activity of RNAase on ribonucleic acid, although a large change in the binding constant towards cytidine cyclic phosphate was observed. The modification can be inhibited by addition of the competitive inhibitor cytidine 2′(3′)5′-diphosphate and may indicate that Tyr 73 is the most exposed residue or has a unique reactivity towards this reactive substrate analog." @default.
- W2067785703 created "2016-06-24" @default.
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- W2067785703 date "1978-01-01" @default.
- W2067785703 modified "2023-10-14" @default.
- W2067785703 title "Modification of a specific tyrosine residue of ribonuclease A with a diazonium inhibitor analog" @default.
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- W2067785703 doi "https://doi.org/10.1016/0005-2795(78)90450-6" @default.
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