FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067792022> ?p ?o ?g. }

• W2067792022 endingPage "4402" @default.
• W2067792022 startingPage "4398" @default.
• W2067792022 abstract "The aldosterone-to-renin ratio (ARR) is a marker of aldosterone activity in hypertension. We examined the relationship of the ARR to the distribution of two biallelic polymorphisms at the CYP11B2 gene locus. One polymorphism affects a putative steroidogenic factor-1 binding site (-344 T/C) in the 5'-regulatory region, whereas the other marker reflects replacement of the intron-2 from CYP11B2 with that from the neighboring gene encoding 11beta-hydroxylase (CYP11B1; wild-type/conversion). We studied consecutive referrals to the Tayside hypertension clinic in 1998. Because the specificity of ARR (pmol/liter/ng/ml/h) for hyperaldosteronism increases with its threshold, ARRs of at least 750 and 1000 were used. A total of 375 patients were assessed; 86.9% had complete data. There were significant excesses of steroidogenic factor-1 (T) (ARR >/= 750, 0.62 vs. 0.51, P = 0.014; ARR >/= 1000, 0.63 vs. 0.51, P = 0.039) and intron-2 (conversion) (ARR >/= 750, 0.49 vs. 0.41, P = 0.205; ARR >/= 1000, 0.54 vs. 0.41, P = 0.029) alleles in patients with a raised ARR. The odds ratio for a raised ARR was 2.27 [95% confidence interval, 1.01, 5.09; P < 0.05] comparing patients with a homozygous haplotype for these alleles with those without any such alleles, and this risk increased with age. This study supports the notion that there is a genetic component that regulates aldosterone production and that hyperaldosteronism might develop over time in susceptible individuals." @default.
• W2067792022 created "2016-06-24" @default.
• W2067792022 creator A5019200508 @default.
• W2067792022 creator A5032221961 @default.
• W2067792022 creator A5038552816 @default.
• W2067792022 creator A5051452799 @default.
• W2067792022 creator A5052917636 @default.
• W2067792022 creator A5053151541 @default.
• W2067792022 creator A5058596964 @default.
• W2067792022 creator A5065547000 @default.
• W2067792022 creator A5078047535 @default.
• W2067792022 creator A5081246882 @default.
• W2067792022 date "2002-09-01" @default.
• W2067792022 modified "2023-10-15" @default.
• W2067792022 title "Variation at the Aldosterone Synthase (CYP11B2) Locus Contributes to Hypertension in Subjects with a Raised Aldosterone-to-Renin Ratio" @default.
• W2067792022 cites W1973158775 @default.
• W2067792022 cites W1977014222 @default.
• W2067792022 cites W1977415769 @default.
• W2067792022 cites W1984312453 @default.
• W2067792022 cites W1984828684 @default.
• W2067792022 cites W1985770217 @default.
• W2067792022 cites W2014072417 @default.
• W2067792022 cites W2018688812 @default.
• W2067792022 cites W2038958095 @default.
• W2067792022 cites W2039397242 @default.
• W2067792022 cites W2064320461 @default.
• W2067792022 cites W2066598157 @default.
• W2067792022 cites W2073833126 @default.
• W2067792022 cites W2085100607 @default.
• W2067792022 cites W2114892112 @default.
• W2067792022 cites W2116106734 @default.
• W2067792022 cites W2135207001 @default.
• W2067792022 cites W2145366887 @default.
• W2067792022 cites W2146059439 @default.
• W2067792022 cites W2149996020 @default.
• W2067792022 cites W2154375739 @default.
• W2067792022 cites W2161212879 @default.
• W2067792022 cites W2059351949 @default.
• W2067792022 doi "https://doi.org/10.1210/jc.2001-012070" @default.
• W2067792022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12213905" @default.
• W2067792022 hasPublicationYear "2002" @default.
• W2067792022 type Work @default.
• W2067792022 sameAs 2067792022 @default.
• W2067792022 citedByCount "105" @default.
• W2067792022 countsByYear W20677920222012 @default.
• W2067792022 countsByYear W20677920222013 @default.
• W2067792022 countsByYear W20677920222014 @default.
• W2067792022 countsByYear W20677920222015 @default.
• W2067792022 countsByYear W20677920222018 @default.
• W2067792022 countsByYear W20677920222019 @default.
• W2067792022 countsByYear W20677920222020 @default.
• W2067792022 countsByYear W20677920222022 @default.
• W2067792022 countsByYear W20677920222023 @default.
• W2067792022 crossrefType "journal-article" @default.
• W2067792022 hasAuthorship W2067792022A5019200508 @default.
• W2067792022 hasAuthorship W2067792022A5032221961 @default.
• W2067792022 hasAuthorship W2067792022A5038552816 @default.
• W2067792022 hasAuthorship W2067792022A5051452799 @default.
• W2067792022 hasAuthorship W2067792022A5052917636 @default.
• W2067792022 hasAuthorship W2067792022A5053151541 @default.
• W2067792022 hasAuthorship W2067792022A5058596964 @default.
• W2067792022 hasAuthorship W2067792022A5065547000 @default.
• W2067792022 hasAuthorship W2067792022A5078047535 @default.
• W2067792022 hasAuthorship W2067792022A5081246882 @default.
• W2067792022 hasBestOaLocation W20677920221 @default.
• W2067792022 hasConcept C104317684 @default.
• W2067792022 hasConcept C126322002 @default.
• W2067792022 hasConcept C134018914 @default.
• W2067792022 hasConcept C155392382 @default.
• W2067792022 hasConcept C180754005 @default.
• W2067792022 hasConcept C197754878 @default.
• W2067792022 hasConcept C198710026 @default.
• W2067792022 hasConcept C2776292634 @default.
• W2067792022 hasConcept C2778525890 @default.
• W2067792022 hasConcept C2780249997 @default.
• W2067792022 hasConcept C2780902042 @default.
• W2067792022 hasConcept C54355233 @default.
• W2067792022 hasConcept C71315377 @default.
• W2067792022 hasConcept C71924100 @default.
• W2067792022 hasConcept C84393581 @default.
• W2067792022 hasConcept C84597430 @default.
• W2067792022 hasConcept C86803240 @default.
• W2067792022 hasConceptScore W2067792022C104317684 @default.
• W2067792022 hasConceptScore W2067792022C126322002 @default.
• W2067792022 hasConceptScore W2067792022C134018914 @default.
• W2067792022 hasConceptScore W2067792022C155392382 @default.
• W2067792022 hasConceptScore W2067792022C180754005 @default.
• W2067792022 hasConceptScore W2067792022C197754878 @default.
• W2067792022 hasConceptScore W2067792022C198710026 @default.
• W2067792022 hasConceptScore W2067792022C2776292634 @default.
• W2067792022 hasConceptScore W2067792022C2778525890 @default.
• W2067792022 hasConceptScore W2067792022C2780249997 @default.
• W2067792022 hasConceptScore W2067792022C2780902042 @default.
• W2067792022 hasConceptScore W2067792022C54355233 @default.
• W2067792022 hasConceptScore W2067792022C71315377 @default.
• W2067792022 hasConceptScore W2067792022C71924100 @default.
• W2067792022 hasConceptScore W2067792022C84393581 @default.
• W2067792022 hasConceptScore W2067792022C84597430 @default.

• next