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• W2067796323 abstract "T3 injection into the portal vein of the isolated hypo- and euthyroid liver rapidly stimulated alanine and 14C-α-amino-isobutyric acid uptake, O2-consumption, glucose and urea production, and increased the overall, cytoplasmic and mitochondrial energy state. The concentration of the effector molecules long chain acyl CoA, acetyl-CoA, citrat and AMP remained unchanged. After T3 application no alteration in hepatic cAMP content, protein kinase activation, and in the tissue levels of the intermediates of the Embden-Meyerhof-pathway were observed. Our results indicate that T3 rapidly stimulates hepatic glucose production independently of cAMP by increasing amino acid uptake and mitochondrial ATP regeneration and translocation in the cytoplasmic compartment, thus providing both the precursor and energy for gluconeogenesis." @default.
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• W2067796323 date "1980-09-01" @default.
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• W2067796323 title "Rapid and direct stimulation of hepatic gluconeogenesis by L-triiodothyronine (T3) in the isolated-perfused rat liver" @default.
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• W2067796323 doi "https://doi.org/10.1016/0024-3205(80)90076-4" @default.
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