FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067802991> ?p ?o ?g. }

• W2067802991 endingPage "873" @default.
• W2067802991 startingPage "863" @default.
• W2067802991 abstract "Involvement of Angiotensin II (Ang II) in the regulation of sodium levels by modulating the Na+/H+ exchangers is demonstrated in many tissues. Screening of a mouse 17-day fetus cDNA library with the Angiotensin II receptor AT2 as the bait in yeast two-hybrid assay led us to identify an AT2-interacting mouse fetus peptide that shared 98% amino acid identity with the corresponding region of the human NHE6. NCBI Blast search showed that the clone 6430520C02 (GenBank Accession # AK032326) of the mouse genome project carried the complete sequence of this new mouse NHE6 isoform. The human and mouse NHE6 peptides share 97% overall homology. Further analysis showed that the region spanning the third intracellular loop and C-terminal cytoplasmic tail of the AT2 directly interacted with a 182 amino acid region that spans the predicted 5th intracellular loop and the initial part of the C-terminus of the mouse NHE6 in yeast two-hybrid assay. This 182-amino acid region that interacted with the AT2 also shares 98% homology with the corresponding region of rat NHE6 and therefore is highly conserved across species. We detected widespread expression of this NHE6 isoform in several rat tissues including 10-day fetus, 17-day fetus, and 30-day post-natal tissues of heart, brain, kidney and muscle. Moreover, the AT2 co-immunoiprecipitated with a hemagglutinin tagged NHE6 when expressed in human cell line MCF-7, and activated by AngII. This ligand-dependent complex formation between the AT2 and NHE6 suggests that the hormone Ang II may act as a regulator of NHE6, and Ang II-mediated direct protein-protein interaction between AT2 and NHE6 could be a mechanism for modulating the functions of the ubiquitously expressed NHE6 in different tissues." @default.
• W2067802991 created "2016-06-24" @default.
• W2067802991 creator A5008584237 @default.
• W2067802991 creator A5013430996 @default.
• W2067802991 creator A5018544378 @default.
• W2067802991 creator A5041606146 @default.
• W2067802991 creator A5047793411 @default.
• W2067802991 creator A5078435976 @default.
• W2067802991 creator A5081724961 @default.
• W2067802991 date "2005-05-01" @default.
• W2067802991 modified "2023-09-23" @default.
• W2067802991 title "Ligand-dependent complex formation between the Angiotensin II receptor subtype AT2 and Na+/H+ exchanger NHE6 in mammalian cells" @default.
• W2067802991 cites W1518719712 @default.
• W2067802991 cites W1527240164 @default.
• W2067802991 cites W1575840121 @default.
• W2067802991 cites W1591510379 @default.
• W2067802991 cites W1597215001 @default.
• W2067802991 cites W1606441705 @default.
• W2067802991 cites W1965570459 @default.
• W2067802991 cites W1967561584 @default.
• W2067802991 cites W1967874349 @default.
• W2067802991 cites W1968874083 @default.
• W2067802991 cites W1970747388 @default.
• W2067802991 cites W1974615597 @default.
• W2067802991 cites W1986234964 @default.
• W2067802991 cites W2010031713 @default.
• W2067802991 cites W2011239555 @default.
• W2067802991 cites W2011603738 @default.
• W2067802991 cites W2012756848 @default.
• W2067802991 cites W2013690237 @default.
• W2067802991 cites W2015209631 @default.
• W2067802991 cites W2017817977 @default.
• W2067802991 cites W2024588024 @default.
• W2067802991 cites W2027854976 @default.
• W2067802991 cites W2029475936 @default.
• W2067802991 cites W2032486084 @default.
• W2067802991 cites W2034705994 @default.
• W2067802991 cites W2041792559 @default.
• W2067802991 cites W2042418271 @default.
• W2067802991 cites W2042446681 @default.
• W2067802991 cites W2042618439 @default.
• W2067802991 cites W2043623738 @default.
• W2067802991 cites W2047441503 @default.
• W2067802991 cites W2047844782 @default.
• W2067802991 cites W2047981173 @default.
• W2067802991 cites W2049940861 @default.
• W2067802991 cites W2053596945 @default.
• W2067802991 cites W2054640522 @default.
• W2067802991 cites W2055124499 @default.
• W2067802991 cites W2057441702 @default.
• W2067802991 cites W2078261203 @default.
• W2067802991 cites W2079190466 @default.
• W2067802991 cites W2084766131 @default.
• W2067802991 cites W2087023069 @default.
• W2067802991 cites W2091631803 @default.
• W2067802991 cites W2093459048 @default.
• W2067802991 cites W2105687519 @default.
• W2067802991 cites W2114170740 @default.
• W2067802991 cites W2131033837 @default.
• W2067802991 cites W2132454291 @default.
• W2067802991 cites W2144720482 @default.
• W2067802991 cites W2156249899 @default.
• W2067802991 cites W2157616828 @default.
• W2067802991 cites W2182230456 @default.
• W2067802991 doi "https://doi.org/10.1016/j.peptides.2004.12.015" @default.
• W2067802991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15808917" @default.
• W2067802991 hasPublicationYear "2005" @default.
• W2067802991 type Work @default.
• W2067802991 sameAs 2067802991 @default.
• W2067802991 citedByCount "29" @default.
• W2067802991 countsByYear W20678029912012 @default.
• W2067802991 countsByYear W20678029912013 @default.
• W2067802991 countsByYear W20678029912014 @default.
• W2067802991 countsByYear W20678029912015 @default.
• W2067802991 countsByYear W20678029912017 @default.
• W2067802991 countsByYear W20678029912019 @default.
• W2067802991 countsByYear W20678029912020 @default.
• W2067802991 countsByYear W20678029912021 @default.
• W2067802991 countsByYear W20678029912022 @default.
• W2067802991 crossrefType "journal-article" @default.
• W2067802991 hasAuthorship W2067802991A5008584237 @default.
• W2067802991 hasAuthorship W2067802991A5013430996 @default.
• W2067802991 hasAuthorship W2067802991A5018544378 @default.
• W2067802991 hasAuthorship W2067802991A5041606146 @default.
• W2067802991 hasAuthorship W2067802991A5047793411 @default.
• W2067802991 hasAuthorship W2067802991A5078435976 @default.
• W2067802991 hasAuthorship W2067802991A5081724961 @default.
• W2067802991 hasConcept C104317684 @default.
• W2067802991 hasConcept C114574056 @default.
• W2067802991 hasConcept C153911025 @default.
• W2067802991 hasConcept C165525559 @default.
• W2067802991 hasConcept C167625842 @default.
• W2067802991 hasConcept C170493617 @default.
• W2067802991 hasConcept C178790620 @default.
• W2067802991 hasConcept C185592680 @default.
• W2067802991 hasConcept C187882448 @default.
• W2067802991 hasConcept C189482833 @default.
• W2067802991 hasConcept C2908929049 @default.

• next