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• W2067804517 endingPage "906" @default.
• W2067804517 startingPage "906" @default.
• W2067804517 abstract "The marine annelid Platynereis dumerilii is emerging as a powerful lophotrochozoan experimental model for evolutionary developmental biology (evo-devo) and neurobiology. Recent studies revealed the presence of conserved neuropeptidergic signaling in Platynereis, including vasotocin/neurophysin, myoinhibitory peptide and opioid peptidergic systems. Despite these advances, comprehensive peptidome resources have yet to be reported.The present work describes the neuropeptidome of Platynereis. We established a large transcriptome resource, consisting of stage-specific next-generation sequencing datasets and 77,419 expressed sequence tags. Using this information and a combination of bioinformatic searches and mass spectrometry analyses, we increased the known proneuropeptide (pNP) complement of Platynereis to 98. Based on sequence homology to metazoan pNPs, Platynereis pNPs were grouped into ancient eumetazoan, bilaterian, protostome, lophotrochozoan, and annelid families, and pNPs only found in Platynereis. Compared to the planarian Schmidtea mediterranea, the only other lophotrochozoan with a large-scale pNP resource, Platynereis has a remarkably full complement of conserved pNPs, with 53 pNPs belonging to ancient eumetazoan or bilaterian families. Our comprehensive search strategy, combined with analyses of sequence conservation, also allowed us to define several novel lophotrochozoan and annelid pNP families. The stage-specific transcriptome datasets also allowed us to map changes in pNP expression throughout the Platynereis life cycle.The large repertoire of conserved pNPs in Platynereis highlights the usefulness of annelids in comparative neuroendocrinology. This work establishes a reference dataset for comparative peptidomics in lophotrochozoans and provides the basis for future studies of Platynereis peptidergic signaling." @default.
• W2067804517 created "2016-06-24" @default.
• W2067804517 creator A5001119999 @default.
• W2067804517 creator A5009803768 @default.
• W2067804517 creator A5038258123 @default.
• W2067804517 creator A5067586504 @default.
• W2067804517 creator A5083327817 @default.
• W2067804517 creator A5085238149 @default.
• W2067804517 date "2013-01-01" @default.
• W2067804517 modified "2023-10-12" @default.
• W2067804517 title "The neuropeptide complement of the marine annelid Platynereis dumerilii" @default.
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• W2067804517 doi "https://doi.org/10.1186/1471-2164-14-906" @default.

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