Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067804578> ?p ?o ?g. }
- W2067804578 endingPage "23" @default.
- W2067804578 startingPage "7" @default.
- W2067804578 abstract "The process of RNA editing involves the modification of mRNA at specific sites by adenosine deaminases that act on RNA (ADAR) enzymes. By catalyzing the conversion of adenosine to inosine, these enzymes alter the way in which the mRNA is translated, and consequently alter the primary structure of the resultant proteins. The serotonin (5HT) 2C receptor (5HT2CR) is currently the only known member of the superfamily of seven transmembrane domain receptors (7TMRs) to undergo this modification, and provides a fascinating case study in the effects of such changes. Here we review the current state of knowledge surrounding the editing of the 5HT2CR, the stark differences in signalling arising due to this process, and the potential for (and difficulties in) exploiting the phenomenon for improved therapeutic intervention in various neurological disorders." @default.
- W2067804578 created "2016-06-24" @default.
- W2067804578 creator A5016689951 @default.
- W2067804578 creator A5021082373 @default.
- W2067804578 creator A5056899194 @default.
- W2067804578 creator A5075463548 @default.
- W2067804578 date "2008-07-01" @default.
- W2067804578 modified "2023-10-16" @default.
- W2067804578 title "RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function" @default.
- W2067804578 cites W10444974 @default.
- W2067804578 cites W1524239110 @default.
- W2067804578 cites W1536524213 @default.
- W2067804578 cites W1547213195 @default.
- W2067804578 cites W1554938697 @default.
- W2067804578 cites W1579285271 @default.
- W2067804578 cites W1580869285 @default.
- W2067804578 cites W1623913572 @default.
- W2067804578 cites W1684978948 @default.
- W2067804578 cites W1695992398 @default.
- W2067804578 cites W1758644208 @default.
- W2067804578 cites W1889050100 @default.
- W2067804578 cites W1908965723 @default.
- W2067804578 cites W1964322969 @default.
- W2067804578 cites W1965926903 @default.
- W2067804578 cites W1966061481 @default.
- W2067804578 cites W1966935745 @default.
- W2067804578 cites W1968686367 @default.
- W2067804578 cites W1969855549 @default.
- W2067804578 cites W1971682870 @default.
- W2067804578 cites W1974622562 @default.
- W2067804578 cites W1975371972 @default.
- W2067804578 cites W1976414671 @default.
- W2067804578 cites W1976651077 @default.
- W2067804578 cites W1978934025 @default.
- W2067804578 cites W1982144267 @default.
- W2067804578 cites W1985256582 @default.
- W2067804578 cites W1990991409 @default.
- W2067804578 cites W1991278351 @default.
- W2067804578 cites W1991558577 @default.
- W2067804578 cites W1991974510 @default.
- W2067804578 cites W1993000687 @default.
- W2067804578 cites W1993266955 @default.
- W2067804578 cites W1994075403 @default.
- W2067804578 cites W1994299993 @default.
- W2067804578 cites W1994792053 @default.
- W2067804578 cites W1994901510 @default.
- W2067804578 cites W1998774082 @default.
- W2067804578 cites W1999261716 @default.
- W2067804578 cites W1999633405 @default.
- W2067804578 cites W2001252937 @default.
- W2067804578 cites W2003545653 @default.
- W2067804578 cites W2003849576 @default.
- W2067804578 cites W2005148058 @default.
- W2067804578 cites W2006178602 @default.
- W2067804578 cites W2006406883 @default.
- W2067804578 cites W2006462446 @default.
- W2067804578 cites W2008374290 @default.
- W2067804578 cites W2011635150 @default.
- W2067804578 cites W2012573248 @default.
- W2067804578 cites W2014001501 @default.
- W2067804578 cites W2014222062 @default.
- W2067804578 cites W2017196201 @default.
- W2067804578 cites W2018778450 @default.
- W2067804578 cites W2022681782 @default.
- W2067804578 cites W2022814180 @default.
- W2067804578 cites W2024197904 @default.
- W2067804578 cites W2026313856 @default.
- W2067804578 cites W2027238991 @default.
- W2067804578 cites W2027971128 @default.
- W2067804578 cites W2030600537 @default.
- W2067804578 cites W2030642011 @default.
- W2067804578 cites W2031875909 @default.
- W2067804578 cites W2033045982 @default.
- W2067804578 cites W2033246629 @default.
- W2067804578 cites W2034951640 @default.
- W2067804578 cites W2038500073 @default.
- W2067804578 cites W2042071572 @default.
- W2067804578 cites W2043724929 @default.
- W2067804578 cites W2047742792 @default.
- W2067804578 cites W2050264591 @default.
- W2067804578 cites W2051148199 @default.
- W2067804578 cites W2053785051 @default.
- W2067804578 cites W2054086992 @default.
- W2067804578 cites W2054560514 @default.
- W2067804578 cites W2055839478 @default.
- W2067804578 cites W2058011091 @default.
- W2067804578 cites W2059477617 @default.
- W2067804578 cites W2060305535 @default.
- W2067804578 cites W2068275172 @default.
- W2067804578 cites W2070280529 @default.
- W2067804578 cites W2071014763 @default.
- W2067804578 cites W2073685549 @default.
- W2067804578 cites W2074202763 @default.
- W2067804578 cites W2074350307 @default.
- W2067804578 cites W2074562954 @default.
- W2067804578 cites W2077894059 @default.
- W2067804578 cites W2081905164 @default.
- W2067804578 cites W2082826363 @default.