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- W2067805105 abstract "Plasma membrane vesicle preparations from mouse cerebral cortex actively accumulated [3H]serotonin upon the imposition of a K+ gradient (in > out), a Na+ gradient (out > in), and the presence of external Cl−. Maximal stimulation of uptake by internal K+ occurred at 15 mM and half-maximal stimulation at 2 mM. Internal K+ did not enhance uptake merely via generation of a membrane potential because simultaneous parallel increases in internal and external K+ concentration also stimulated uptake. External Cl− increased serotonin uptake with a Km of 18 mM and a Hill number of 1.0, suggesting a requirement for one chloride ion for transport. Uptake could not be driven by internal H+ instead of K+. Estimation of the membrane potential by the distribution of triphenylmethylphosphonium ion showed a modest effect of valinomycin (1–20 μM) in increasing the potential from −19 to −31 mV accompanied by an increase in serotonin uptake. Proton ionophores prevented this effect of valinomycin and, by themselves, reduced the potential to −6 mV, but did not affect serotonin transport. A model is proposed for serotonin transport in brain plasma membrane vesicles that is similar to the model for porcine blood platelet vesicles as far as electroneutrality and stimulation by K+ Na+, and Cl− are concerned, but that is different in substitution of internal H+ for K+." @default.
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- W2067805105 title "Role of ions and membrane potential in uptake of serotonin into plasma membrane vesicles from mouse brain" @default.
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- W2067805105 doi "https://doi.org/10.1016/0006-2952(89)90062-2" @default.
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