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• W2067805552 abstract "Coronary heart disease (CHD), the major cause of morbidity and mortality in patients with type 2 diabetes, cannot be entirely explained by the presence of conventional risk factors. 1 Hayden J.M. Reaven P.D. Cardiovascular disease in diabetes mellitus type 2 a potential role for novel cardiovascular risk factors. Curr Opin Lipidol. 2000; : 11519-11528 Google Scholar Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. 2 Vallance P. Leone A. Calver A. Collier J. Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol. 1992; 12: S60-S62 Crossref Scopus (420) Google Scholar Plasma ADMA concentrations have been shown to be elevated in animals and patients with hypercholesterolemia and atherosclerosis, 3 Bode-Boger S.M. Boger R.H. Kienke S. Junker W. Frolich J.C. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun. 1996; 219: 598-603 Crossref PubMed Scopus (292) Google Scholar , 4 Boger R.H. Bode-Boger S.M. Szuba A. Tsao P.S. Chan J.R. Tangphao O. Blaschke T.F. Cooke J.P. Asymmetric dimethylarginine (ADMA) its role in hypercholesterolemia. Circulation. 1998; 98: 1842-1847 Crossref PubMed Scopus (1084) Google Scholar , 5 Cooke J.P. Does ADMA cause endothelial dysfunction?. Arterioscler Thromb Vasc Biol. 2000; 20: 2032-2037 Crossref PubMed Scopus (542) Google Scholar and intracellular concentrations of ADMA are increased in regenerated endothelial cells after balloon injury in rabbits with alloxan-induced hyperglycemia. 6 Masuda H. Goto M. Tamaoki S. Azuma H. Accelerated intimal hyperplasma and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycemia. Br J Pharmacol. 1999; 126: 211-218 Crossref PubMed Scopus (98) Google Scholar Thus, we hypothesized that increased plasma concentrations of ADMA, by inhibiting NO synthase, could play a role in the depressed endothelial cell-dependent vasodilator responses that have been described in patients with type 2 diabetes. 7 Watts G.F. O’Brien S.F. Silvester W. Millar J.A. Impaired endothelium-dependent and independent dilation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes role of dyslipidemia. Clin Sci. 1996; 91: 567-573 PubMed Google Scholar , 8 Williams S.B. Cusco J.A. Roddy M.-A. Johnstone M.T. Creager M.A. Impaired nitric oxide-mediated vasodilation in patients with non-insulin dependent diabetes mellitus. J Am Coll Cardiol. 1996; 27: 567-574 Abstract Full Text PDF PubMed Scopus (874) Google Scholar , 9 Avogaro A. Piarulli F. Valerio A. Miola M. Calveri M. Pavan P. Vicini P. Cobelli C. Tiengo A. Calo L. Del Prato S. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients. Diabetes. 1997; 46: 1040-1046 Crossref PubMed Scopus (90) Google Scholar Because endothelial dysfunction is an early event in the process of atherogenesis, 10 Ross R. Atherosclerosis an inflammatory disease. N Engl J Med. 1999; 340: 115-126 Crossref PubMed Scopus (19069) Google Scholar we also hypothesized that plasma ADMA concentrations are elevated in hyperglycemic patients with type 2 diabetes, and could contribute to the accelerated atherogenesis in these persons. To begin evaluation of these hypotheses, we compared plasma ADMA concentrations in normal volunteers with those in patients with type 2 diabetes." @default.
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• W2067805552 date "2001-11-01" @default.
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• W2067805552 title "Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus" @default.
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• W2067805552 doi "https://doi.org/10.1016/s0002-9149(01)02063-x" @default.
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