Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067821337> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2067821337 endingPage "S147" @default.
- W2067821337 startingPage "S141" @default.
- W2067821337 abstract "Latanoprost, a prodrug of a prostaglandin F(2alpha) analog, is a potent ocular hypotensive agent, reducing intraocular pressure (IOP) primarily by increasing aqueous humor drainage through the uveoscleral outflow pathway. Initial assessments in animals found that high concentrations of cholinergic agonists reduced drainage through this pathway and attenuated the effects of a PGF(2alpha) analog. This raised the question of whether latanoprost would be effective when added to the treatment regimen of patients on pilocarpine or strong miotics. In published clinical studies, latanoprost was additive to the maximally tolerated medical therapy (which included cholinergic agonists) of glaucoma patients. Multiple doses of physostigmine in healthy volunteers did not block the effect of a single drop of latanoprost during a 1-day study. One study attempting to find the optimal timing of administration of latanoprost and pilocarpine claimed to show that additivity was best when pilocarpine was given one hour after latanoprost in the evening. Two other studies found that the timing of the doses was not important. To explain the additivity of latanoprost and pilocarpine, aqueous humor dynamics were assessed in ocular hypertensive patients treated for 1 week with each drug alone and then for one week in combination. The results showed that latanoprost increased uveoscleral outflow, pilocarpine increased outflow facility, and pilocarpine did not block or attenuate the uveoscleral outflow effect of latanoprost. The result was greater IOP reduction when these drugs were used in combination than when either drug was used alone. All available evidence demonstrates that addition of latanoprost to the treatment regime of patients already taking cholinergic agonists is an effective, although not necessarily the preferred, combination of medications for the treatment of elevated IOP." @default.
- W2067821337 created "2016-06-24" @default.
- W2067821337 creator A5030475959 @default.
- W2067821337 creator A5039302002 @default.
- W2067821337 creator A5091104086 @default.
- W2067821337 date "2002-08-01" @default.
- W2067821337 modified "2023-10-06" @default.
- W2067821337 title "Latanoprost and Cholinergic Agonists in Combination" @default.
- W2067821337 cites W1963522904 @default.
- W2067821337 cites W1977730321 @default.
- W2067821337 cites W1998300972 @default.
- W2067821337 cites W2004206046 @default.
- W2067821337 cites W2006726419 @default.
- W2067821337 cites W2008057629 @default.
- W2067821337 cites W2016305812 @default.
- W2067821337 cites W2059589670 @default.
- W2067821337 cites W2065437588 @default.
- W2067821337 cites W2066098313 @default.
- W2067821337 cites W2076406860 @default.
- W2067821337 cites W2080504583 @default.
- W2067821337 cites W2090868178 @default.
- W2067821337 cites W2114271694 @default.
- W2067821337 cites W2117309546 @default.
- W2067821337 cites W2125107554 @default.
- W2067821337 cites W2135124962 @default.
- W2067821337 cites W2151367379 @default.
- W2067821337 cites W2158974692 @default.
- W2067821337 cites W23269542 @default.
- W2067821337 doi "https://doi.org/10.1016/s0039-6257(02)00309-0" @default.
- W2067821337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12204711" @default.
- W2067821337 hasPublicationYear "2002" @default.
- W2067821337 type Work @default.
- W2067821337 sameAs 2067821337 @default.
- W2067821337 citedByCount "25" @default.
- W2067821337 countsByYear W20678213372013 @default.
- W2067821337 countsByYear W20678213372014 @default.
- W2067821337 countsByYear W20678213372017 @default.
- W2067821337 countsByYear W20678213372018 @default.
- W2067821337 countsByYear W20678213372019 @default.
- W2067821337 countsByYear W20678213372020 @default.
- W2067821337 countsByYear W20678213372022 @default.
- W2067821337 crossrefType "journal-article" @default.
- W2067821337 hasAuthorship W2067821337A5030475959 @default.
- W2067821337 hasAuthorship W2067821337A5039302002 @default.
- W2067821337 hasAuthorship W2067821337A5091104086 @default.
- W2067821337 hasConcept C118487528 @default.
- W2067821337 hasConcept C118552586 @default.
- W2067821337 hasConcept C2775859210 @default.
- W2067821337 hasConcept C2775910092 @default.
- W2067821337 hasConcept C2776521421 @default.
- W2067821337 hasConcept C2776663719 @default.
- W2067821337 hasConcept C2776740260 @default.
- W2067821337 hasConcept C2777204577 @default.
- W2067821337 hasConcept C2778186239 @default.
- W2067821337 hasConcept C2778527774 @default.
- W2067821337 hasConcept C2781092963 @default.
- W2067821337 hasConcept C42219234 @default.
- W2067821337 hasConcept C71924100 @default.
- W2067821337 hasConcept C98274493 @default.
- W2067821337 hasConceptScore W2067821337C118487528 @default.
- W2067821337 hasConceptScore W2067821337C118552586 @default.
- W2067821337 hasConceptScore W2067821337C2775859210 @default.
- W2067821337 hasConceptScore W2067821337C2775910092 @default.
- W2067821337 hasConceptScore W2067821337C2776521421 @default.
- W2067821337 hasConceptScore W2067821337C2776663719 @default.
- W2067821337 hasConceptScore W2067821337C2776740260 @default.
- W2067821337 hasConceptScore W2067821337C2777204577 @default.
- W2067821337 hasConceptScore W2067821337C2778186239 @default.
- W2067821337 hasConceptScore W2067821337C2778527774 @default.
- W2067821337 hasConceptScore W2067821337C2781092963 @default.
- W2067821337 hasConceptScore W2067821337C42219234 @default.
- W2067821337 hasConceptScore W2067821337C71924100 @default.
- W2067821337 hasConceptScore W2067821337C98274493 @default.
- W2067821337 hasLocation W20678213371 @default.
- W2067821337 hasLocation W20678213372 @default.
- W2067821337 hasOpenAccess W2067821337 @default.
- W2067821337 hasPrimaryLocation W20678213371 @default.
- W2067821337 hasRelatedWork W1848269197 @default.
- W2067821337 hasRelatedWork W2002420118 @default.
- W2067821337 hasRelatedWork W2029138361 @default.
- W2067821337 hasRelatedWork W2042369386 @default.
- W2067821337 hasRelatedWork W2054793874 @default.
- W2067821337 hasRelatedWork W2067821337 @default.
- W2067821337 hasRelatedWork W2084415986 @default.
- W2067821337 hasRelatedWork W2086830572 @default.
- W2067821337 hasRelatedWork W2470999435 @default.
- W2067821337 hasRelatedWork W3201201667 @default.
- W2067821337 hasVolume "47" @default.
- W2067821337 isParatext "false" @default.
- W2067821337 isRetracted "false" @default.
- W2067821337 magId "2067821337" @default.
- W2067821337 workType "article" @default.