FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067836358> ?p ?o ?g. }

• W2067836358 endingPage "119" @default.
• W2067836358 startingPage "113" @default.
• W2067836358 abstract "The effects of CPU‐23 (1‐{1‐[(6‐methoxyl)‐naphth‐2‐yl]}‐propyl‐2‐(1‐piperidine)‐acetyl‐6,7‐dimethyoxy‐1,2,3,4‐tetra‐hydroisoquinoline) were studied on mechanical and electrical activities, and intracellular free calcium ([Ca 2+ ] i ) of isolated cardiac tissues in order to investigate its spectrum and mechanisms of action in the heart. Its antiarrhythmic and haemodynamic effects in pentobarbitone‐anaesthetized rats subjected to coronary artery ligation were also evaluated. CPU‐23 at 10 −6 ‐10 −4 m markedly inhibited slow action potential characteristics in guinea‐pig papillary muscles and pace‐maker action potential of rabbit sinoatrial node. It affected fast action potential only at 10 −4 M. None of the effects of CPU‐23 was reversed by washout for up to 2 h. Like nifedipine and diltiazem, CPU‐23 decreased the heart rate of the isolated perfused heart of the rat. However, in contrast to these two classical calcium antagonists which dose‐dependently inhibited the force of contraction, CPU‐23 inhibited and stimulated the force of contraction at 10 −7 ‐3 × 10 −6 m and 10 −5 m , respectively. CPU‐23 at 10 −6 ‐10 −5 m inhibited the KCl‐induced [Ca 2+ ] i increase in the Ca 2+ medium, but did not affect the caffeine‐induced [Ca 2+ ] i increase in the Ca 2+ ‐free medium in isolated ventricular myocytes. CPU‐23 at 1–5 mg kg −1 reduced dose‐dependently ventricular arrhythmias including ventricular ectopic beats, VT and VF as well as mortality during coronary artery ligation. At 2.5–5 mg kg −1 it even abolished VF, which was accompanied by 100% survival. It is suggested that CPU‐23 has calcium antagonistic properties in cardiac tissues. It selectively blocks the transmembrane influx of extracellular Ca 2+ through Ca 2+ channels, thus reducing the heart rate and developed tension, altering the slow action potential characteristics and producing antiarrhythmic effect against ischaemic arrhythmias." @default.
• W2067836358 created "2016-06-24" @default.
• W2067836358 creator A5002276429 @default.
• W2067836358 creator A5027564028 @default.
• W2067836358 creator A5038576395 @default.
• W2067836358 creator A5053257075 @default.
• W2067836358 date "1993-05-01" @default.
• W2067836358 modified "2023-10-18" @default.
• W2067836358 title "Calcium antagonistic and antiarrhythmic actions of CPU-23, a substituted tetrahydroisoquinoline" @default.
• W2067836358 cites W1967683461 @default.
• W2067836358 cites W1971892383 @default.
• W2067836358 cites W1973466727 @default.
• W2067836358 cites W1991753441 @default.
• W2067836358 cites W1996024251 @default.
• W2067836358 cites W2035446448 @default.
• W2067836358 cites W2038613484 @default.
• W2067836358 cites W2043154461 @default.
• W2067836358 cites W2045753865 @default.
• W2067836358 cites W2045954035 @default.
• W2067836358 cites W2052698671 @default.
• W2067836358 cites W2052937547 @default.
• W2067836358 cites W2055039403 @default.
• W2067836358 cites W2056548595 @default.
• W2067836358 cites W2066332409 @default.
• W2067836358 cites W2066850200 @default.
• W2067836358 cites W2067486732 @default.
• W2067836358 cites W2072302478 @default.
• W2067836358 cites W2081563063 @default.
• W2067836358 cites W2141260882 @default.
• W2067836358 cites W2167018254 @default.
• W2067836358 cites W2173520866 @default.
• W2067836358 cites W2357148948 @default.
• W2067836358 cites W4214760864 @default.
• W2067836358 cites W4235958696 @default.
• W2067836358 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13539.x" @default.
• W2067836358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175576" @default.
• W2067836358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8495235" @default.
• W2067836358 hasPublicationYear "1993" @default.
• W2067836358 type Work @default.
• W2067836358 sameAs 2067836358 @default.
• W2067836358 citedByCount "44" @default.
• W2067836358 countsByYear W20678363582013 @default.
• W2067836358 countsByYear W20678363582015 @default.
• W2067836358 countsByYear W20678363582016 @default.
• W2067836358 countsByYear W20678363582021 @default.
• W2067836358 crossrefType "journal-article" @default.
• W2067836358 hasAuthorship W2067836358A5002276429 @default.
• W2067836358 hasAuthorship W2067836358A5027564028 @default.
• W2067836358 hasAuthorship W2067836358A5038576395 @default.
• W2067836358 hasAuthorship W2067836358A5053257075 @default.
• W2067836358 hasBestOaLocation W20678363582 @default.
• W2067836358 hasConcept C126322002 @default.
• W2067836358 hasConcept C163415756 @default.
• W2067836358 hasConcept C185592680 @default.
• W2067836358 hasConcept C2777953023 @default.
• W2067836358 hasConcept C2778500429 @default.
• W2067836358 hasConcept C2778542873 @default.
• W2067836358 hasConcept C2779066535 @default.
• W2067836358 hasConcept C42219234 @default.
• W2067836358 hasConcept C519063684 @default.
• W2067836358 hasConcept C71924100 @default.
• W2067836358 hasConcept C84393581 @default.
• W2067836358 hasConceptScore W2067836358C126322002 @default.
• W2067836358 hasConceptScore W2067836358C163415756 @default.
• W2067836358 hasConceptScore W2067836358C185592680 @default.
• W2067836358 hasConceptScore W2067836358C2777953023 @default.
• W2067836358 hasConceptScore W2067836358C2778500429 @default.
• W2067836358 hasConceptScore W2067836358C2778542873 @default.
• W2067836358 hasConceptScore W2067836358C2779066535 @default.
• W2067836358 hasConceptScore W2067836358C42219234 @default.
• W2067836358 hasConceptScore W2067836358C519063684 @default.
• W2067836358 hasConceptScore W2067836358C71924100 @default.
• W2067836358 hasConceptScore W2067836358C84393581 @default.
• W2067836358 hasIssue "1" @default.
• W2067836358 hasLocation W20678363581 @default.
• W2067836358 hasLocation W20678363582 @default.
• W2067836358 hasLocation W20678363583 @default.
• W2067836358 hasLocation W20678363584 @default.
• W2067836358 hasOpenAccess W2067836358 @default.
• W2067836358 hasPrimaryLocation W20678363581 @default.
• W2067836358 hasRelatedWork W1851179650 @default.
• W2067836358 hasRelatedWork W1992051646 @default.
• W2067836358 hasRelatedWork W2020059354 @default.
• W2067836358 hasRelatedWork W2050500654 @default.
• W2067836358 hasRelatedWork W2143657289 @default.
• W2067836358 hasRelatedWork W2313529107 @default.
• W2067836358 hasRelatedWork W2366943995 @default.
• W2067836358 hasRelatedWork W2367045735 @default.
• W2067836358 hasRelatedWork W2383871815 @default.
• W2067836358 hasRelatedWork W3149438219 @default.
• W2067836358 hasVolume "109" @default.
• W2067836358 isParatext "false" @default.
• W2067836358 isRetracted "false" @default.
• W2067836358 magId "2067836358" @default.
• W2067836358 workType "article" @default.