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- W2067839819 abstract "1 Prednisolone binding in human serum and to recrystallized human serum albumin was measured by continuous ultrafiltration. 2 At serum concentrations of prednisolone up to 0.6 micron, 95.0% was bound but at higher concentrations the binding became non-linear falling to 80.5% at 1.8 microns. At even higher concentrations binding in serum became linear again and paralleled the binding to albumin which was linear throughout the entire range of prednisolone concentrations. 3 A binding model was proposed which included a saturable component attributable to binding to transcortin and a non-saturable binding to albumin. 4 Computer simulations using the experimentally determined binding parameters of the model indicated that binding in serum was critically dependent on transcortin concentration and almost independent of albumin concentration." @default.
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- W2067839819 date "1982-11-01" @default.
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- W2067839819 title "The binding of prednisolone in human serum and to recrystallized human albumin in vitro." @default.
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- W2067839819 doi "https://doi.org/10.1111/j.1365-2125.1982.tb04954.x" @default.
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