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- W2067846564 abstract "This report is concerned with the comparative aspects of disposition and conjugation of 3-trifluoromethyl-4-nitrophenol (TFM), a selective sea lamprey larvicide in sea lamprey (Petromyzon marinus) and rainbow trout (Salmo gairdneri). When exposed to identical water concentrations of TFM, sea lamprey ammocoetes exhibited a higher rate of accumulation and an increased steady-state level of TFM compared to trout. Regardless of the life stage of sea lamprey or size of trout studied, sea lamprey revealed a higher concentration of free TFM in blood and tissues. The higher concentration of TFM in lamprey blood was demonstrated at a variety of water concentrations of TFM. In vitro glucuronyl transferase assays demonstrated that the sea lamprey had a lower rate of formation of TFM glucuronide when compared to trout. In vivo, sea lamprey exhibited a much higher ratio of free to conjugated TFM than trout. Pretreatment of sea lamprey and trout with salicylamide, an inhibitor of glucuronyl transferase, shifted the LC50 for trout from 9.7 mg/liter to 3.6 mg/liter and did not alter the LC50 for sea lamprey." @default.
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- W2067846564 title "Role of glucuronide formation in the selective toxicity of 3-trifluoromethyl-4-nitrophenol (TFM) for the sea lamprey: comparative aspects of TFM uptake and conjugation in sea lamprey and rainbow trout" @default.
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- W2067846564 doi "https://doi.org/10.1016/0041-008x(75)90063-0" @default.
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