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• W2067847215 abstract "In membranes of myeloid differentiated HL 60 cells, the chemotactic peptide FMLP stimulates phospholipase C via a pertussis toxin‐sensitive G protein. FMLP markedly stimulates the cholera toxin‐dependent ADP‐ribosylation of a 40 kDa protein in these membranes. This effect of FMLP is inhibited by GTP and GTP[S], and is almost completely abolished in membranes of pertussis toxin‐pretreated HL 60 cells. Treatment of HL 60 membranes with cholera toxin and NAD markedly inhibits FMLP‐stimulated high affinity GTPase. These results suggest that a 40 kDa G protein sensitive to both pertussis and cholera toxin functionally interacts with the formyl peptide receptor of HL 60 cells and, thus, very likely is the G protein that stimulates phospholipase C in this system." @default.
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• W2067847215 date "1987-11-16" @default.
• W2067847215 modified "2023-10-14" @default.
• W2067847215 title "Receptor-mediated ADP-ribosylation of a phospholipase C-stimulating G protein" @default.
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• W2067847215 doi "https://doi.org/10.1016/0014-5793(87)80451-9" @default.
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