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• W2067855423 abstract "We present extensions to our quasi-2D cellular automata spheroid model that add a cellular kinetics module together with an irradiation and repair module. Significantly, our approach is not based on the Linear Quadratic (LQ) model, instead, we propose a simple two-parameter, algorithmic model which captures the essential biological features of irradiation-induced cell death, repair and associated cell cycle delays. This approach allows us to estimate directly the underlying irradiation-induced cell survival probability. We present the calibration of this extended model both with and without the application of single irradiation doses to the commonly studied (in vitro) EMT6/Ro (mammary carcinoma) cell line. A comparison of the estimated underlying cell survival probability with the in vitro survival probability data confirms the expected differences in the measures." @default.
• W2067855423 created "2016-06-24" @default.
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• W2067855423 date "2013-03-01" @default.
• W2067855423 modified "2023-10-05" @default.
• W2067855423 title "A numerical model of EMT6/Ro spheroid dynamics under irradiation: Calibration and estimation of the underlying irradiation-induced cell survival probability" @default.
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• W2067855423 doi "https://doi.org/10.1016/j.jtbi.2012.11.035" @default.
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