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- W2067866652 endingPage "14916" @default.
- W2067866652 startingPage "14898" @default.
- W2067866652 abstract "BRCA1 is a key mediator of DNA repair pathways and participates in the maintenance of the genomic integrity of cells. The control of DNA damage repair mechanisms by BRCA1 is of great interest since molecular defects in this pathway may reflect a predictive value in terms of a cell’s sensitivity to DNA damaging agents or anticancer drugs. BRCA1 has been found to exhibit a hormone-dependent pattern of expression in breast cells. Wild-type BRCA1 is required for the inhibition of the growth of breast tumor cells in response to the pure steroidal ERα antagonist fulvestrant. Also a loss of BRCA1-mediated transcriptional activation of ERα expression results in increased resistance to ERα antagonists. Platinum-based drugs, poly(ADP-ribose) polymerase (PARP) inhibitors, and their combination are currently included in chemotherapy regimens for breast cancer. Preclinical and clinical studies in a BRCA1-defective setting have recently indicated a rationale for the use of these compounds against hereditary breast cancers. Initial findings indicate that neoadjuvant use of cisplatin results in high rates of complete pathological response in patients with breast cancer who have BRCA1 mutations. Cisplatin produces a better response in triple-negative breast cancer (TNBC) than in non-TNBC diseases in both the neoadjuvant and adjuvant settings. This implies that TNBC cells may harbor a dysfunctional BRCA1 repair pathway." @default.
- W2067866652 created "2016-06-24" @default.
- W2067866652 creator A5040953168 @default.
- W2067866652 date "2012-11-14" @default.
- W2067866652 modified "2023-10-16" @default.
- W2067866652 title "A DNA Repair BRCA1 Estrogen Receptor and Targeted Therapy in Breast Cancer" @default.
- W2067866652 cites W1493628203 @default.
- W2067866652 cites W1543908882 @default.
- W2067866652 cites W1546709038 @default.
- W2067866652 cites W1588173849 @default.
- W2067866652 cites W1611268078 @default.
- W2067866652 cites W1955010715 @default.
- W2067866652 cites W1968937305 @default.
- W2067866652 cites W1968943627 @default.
- W2067866652 cites W1969346276 @default.
- W2067866652 cites W1972710550 @default.
- W2067866652 cites W1973030224 @default.
- W2067866652 cites W1973268287 @default.
- W2067866652 cites W1974755980 @default.
- W2067866652 cites W1975307022 @default.
- W2067866652 cites W1975714517 @default.
- W2067866652 cites W1977035912 @default.
- W2067866652 cites W1978727038 @default.
- W2067866652 cites W1979827725 @default.
- W2067866652 cites W1979846193 @default.
- W2067866652 cites W1985921281 @default.
- W2067866652 cites W1989800108 @default.
- W2067866652 cites W1992015449 @default.
- W2067866652 cites W1992261227 @default.
- W2067866652 cites W1995224853 @default.
- W2067866652 cites W1996147631 @default.
- W2067866652 cites W1998499862 @default.
- W2067866652 cites W2002962154 @default.
- W2067866652 cites W2008396969 @default.
- W2067866652 cites W2011658104 @default.
- W2067866652 cites W2011798397 @default.
- W2067866652 cites W2012523195 @default.
- W2067866652 cites W2013809140 @default.
- W2067866652 cites W2014599726 @default.
- W2067866652 cites W2015804997 @default.
- W2067866652 cites W2015925058 @default.
- W2067866652 cites W2017937144 @default.
- W2067866652 cites W2018397818 @default.
- W2067866652 cites W2021044341 @default.
- W2067866652 cites W2022289852 @default.
- W2067866652 cites W2022792151 @default.
- W2067866652 cites W2023739089 @default.
- W2067866652 cites W2024900394 @default.
- W2067866652 cites W2027260716 @default.
- W2067866652 cites W2028605407 @default.
- W2067866652 cites W2031984461 @default.
- W2067866652 cites W2039135884 @default.
- W2067866652 cites W2039143648 @default.
- W2067866652 cites W2039220621 @default.
- W2067866652 cites W2039435798 @default.
- W2067866652 cites W2047368106 @default.
- W2067866652 cites W2050018101 @default.
- W2067866652 cites W2050376635 @default.
- W2067866652 cites W2050684389 @default.
- W2067866652 cites W2051360924 @default.
- W2067866652 cites W2053003311 @default.
- W2067866652 cites W2055468688 @default.
- W2067866652 cites W2059104229 @default.
- W2067866652 cites W2059822676 @default.
- W2067866652 cites W2064246732 @default.
- W2067866652 cites W2067233094 @default.
- W2067866652 cites W2068476548 @default.
- W2067866652 cites W2068638854 @default.
- W2067866652 cites W2068868056 @default.
- W2067866652 cites W2071095686 @default.
- W2067866652 cites W2072981858 @default.
- W2067866652 cites W2074465378 @default.
- W2067866652 cites W2081725177 @default.
- W2067866652 cites W2082064933 @default.
- W2067866652 cites W2082318061 @default.
- W2067866652 cites W2083466846 @default.
- W2067866652 cites W2086038769 @default.
- W2067866652 cites W2089159132 @default.
- W2067866652 cites W2091205535 @default.
- W2067866652 cites W2094053071 @default.
- W2067866652 cites W2095092592 @default.
- W2067866652 cites W2095632857 @default.
- W2067866652 cites W2096843793 @default.
- W2067866652 cites W2097255042 @default.
- W2067866652 cites W2101791074 @default.
- W2067866652 cites W2107931058 @default.
- W2067866652 cites W2111607055 @default.
- W2067866652 cites W2112444654 @default.
- W2067866652 cites W2113825352 @default.
- W2067866652 cites W2118605519 @default.
- W2067866652 cites W2118723994 @default.
- W2067866652 cites W2121415861 @default.
- W2067866652 cites W2125691349 @default.
- W2067866652 cites W2126787895 @default.
- W2067866652 cites W2131994307 @default.
- W2067866652 cites W2132180344 @default.
- W2067866652 cites W2132185105 @default.
- W2067866652 cites W2132286468 @default.