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• W2067870355 abstract "Abstract An efficient synthesis of a series of novel diphenyl N-substituted carbamimidoyl phosphoramidate derivatives was accomplished in two steps. Diphenyl phosphorochloridate (1) was reacted with cyanamide (2) in the presence of 1,4–dimethylpiperazine as a base in THF at 50–55 °C to form an intermediate, diphenyl cyanophosphoramidate (3). Subsequently 3 was reacted with various aromatic/heterocyclic amines (4) in the presence of 1,4–dimethyl piperazine as a base at 55–60 °C to form the corresponding title compounds 5(a-k). The title compounds were tested for antiviral activity against Tobacco mosaic virus (TMV) in vitro, antibacterial and antifungal activities at two different concentrations of 50 and 100 μg/mL. The title compounds exhibited good antiviral and antimicrobial activities when compared to the standards." @default.
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• W2067870355 date "2013-08-16" @default.
• W2067870355 modified "2023-10-02" @default.
• W2067870355 title "Synthesis and Biological Activity of Novel Diphenyl <i>N</i>- Substituted Carbamimidoylphosphoramidate Derivatives" @default.
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• W2067870355 doi "https://doi.org/10.1080/10426507.2012.745075" @default.
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