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- W2067886421 abstract "Proper synaptic function requires the seamless integration of the transport, assembly, and regulation of synaptic components and structures. Inasmuch as the synapse is often distant from the neuronal cell body, newly synthesized synaptic proteins, the precursors of synaptic vesicles, active zone compartments, channels and receptors, and mitochondria, must be transported along lengthy neuronal processes to participate in synaptogenesis. Neuronal transport is mediated by motor proteins that associate with their cargoes via adaptors (or receptors) and that travel along the cytoskeleton network within the neuronal processes. Thus, the identity of membranous protein cargoes and the specificity of motor-cargo interactions are critical for correctly targeting cargoes and properly assembling synapses in developing neurons and in remodeling synapses of mature neurons in response to neuronal activity. In this article, the authors review recent progress in characterizing microtubule- and actin-based motor proteins that are involved in delivering synaptic components and discuss potential mechanisms underlying the formation of motor-receptor-cargo complexes that contribute to synaptogenesis and activity-induced synaptic plasticity." @default.
- W2067886421 created "2016-06-24" @default.
- W2067886421 creator A5018529320 @default.
- W2067886421 creator A5063466701 @default.
- W2067886421 date "2008-11-13" @default.
- W2067886421 modified "2023-10-17" @default.
- W2067886421 title "Molecular Motors and Synaptic Assembly" @default.
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- W2067886421 doi "https://doi.org/10.1177/1073858408329511" @default.
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