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- W2067887158 abstract "To the Editor :We read with great interest the recent article by Yuan et al. [1]. The authors confirm previous observations that female sex and E2 (17β-oestradiol) protect against a rat model of pulmonary hypertension (PH), namely monocrotaline-induced PH (MCT-PH), and that the beneficial effects of E2 in MCT-PH are associated with increased lung nitric oxide, prostacyclin levels and reduced endothelin levels. Furthermore, based on E2 plasma levels and altered expression of key enzymes, they suggest that E2 deficiency may play a role in MCT-PH.We would like to draw attention to another dimension of E2 pharmacology that adds to the complexity of E2 in experimental PH and human pulmonary arterial hypertension (PAH), i.e. the metabolism of E2 to biologically active metabolites. We also would like to discuss the concept that the overall effects of sex and E2 in PH may depend on the model system.Despite the fact that E2 and female sex protect against MCT-PH, surprisingly PAH occurs more frequently in females than …" @default.
- W2067887158 created "2016-06-24" @default.
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- W2067887158 date "2013-05-31" @default.
- W2067887158 modified "2023-09-24" @default.
- W2067887158 title "Complexities of oestradiol pharmacology in pulmonary arterial hypertension" @default.
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- W2067887158 doi "https://doi.org/10.1183/09031936.00164912" @default.
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