FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067917559> ?p ?o ?g. }

• W2067917559 endingPage "48" @default.
• W2067917559 startingPage "41" @default.
• W2067917559 abstract "Abstract The aim of this study was to evaluate the physio-chemical properties and solubility of three pharmaceuticals (Phs): theophylline, 7-(β-hydroxyethyl) theophylline, and theobromine in binary systems in different solvents. The solvents used were water, ethanol, and 1-octanol. Score of the solubility of these substances is being important for their dissolution effect inside the cell, the transportation by body fluids and the penetration possibility of lipid membranes. The Phs were classified to the group of methyl xanthines, which contain purine in their structure. Although they are mainly obtained via chemical synthesis, they can be also found in natural ingredients such as cocoa beans and tea leaves. These drugs are mainly acting on the central nervous system but are also used in the treatment of asthma or blood vessels. Solubility of 7 (β-hydroxyethyl) theophylline and theophylline were tested using synthetic method. In case of theobromine, which solubility is very small in the solvents noted, the spectrophotometric method has been used to measure its solubility. After designating phase diagrams of each of the solubility in the bipolar system, the experimental points have been correlated with the equations: Wilson, NRTL, UNIQUAC. Results show that theophylline and its derivatives show the best solubility from all tested Phs. Another method also used during this study was the differential scanning calorimetry (DSC), which allowed designation of the thermal properties of Phs. The fusion temperature and the enthalpy of melting were measured. Unfortunately, it was not possible to determine the fusion temperature and enthalpy of melting of theobromine, because of the decomposition of Ph at high temperature. The important property tested was the constant acidity, to this end, the spectrophotometric method of Bates–Schwarzenbach was used. Unfortunately, with this method it was not possible to determine the value of pKa 7-(β-hydroxyethyl) theophylline. For other Phs, these values do not differ significantly from those proposed in the literature. Both awareness and knowledge of values of the drug pKa and solubility are important in Phs production. This allows the selection of a suitable solvent and allows estimation of the correct dose and its capacity to absorb in human body." @default.
• W2067917559 created "2016-06-24" @default.
• W2067917559 creator A5009799955 @default.
• W2067917559 creator A5017577532 @default.
• W2067917559 creator A5084917640 @default.
• W2067917559 date "2014-12-01" @default.
• W2067917559 modified "2023-09-27" @default.
• W2067917559 title "The physicochemical properties and solubility of pharmaceuticals – Methyl xanthines" @default.
• W2067917559 cites W1595974186 @default.
• W2067917559 cites W1976779650 @default.
• W2067917559 cites W1998224020 @default.
• W2067917559 cites W2001449443 @default.
• W2067917559 cites W2004278840 @default.
• W2067917559 cites W2010945074 @default.
• W2067917559 cites W2016782873 @default.
• W2067917559 cites W2018524524 @default.
• W2067917559 cites W2019843156 @default.
• W2067917559 cites W2035491424 @default.
• W2067917559 cites W2038022639 @default.
• W2067917559 cites W2038902556 @default.
• W2067917559 cites W2039807526 @default.
• W2067917559 cites W2041282152 @default.
• W2067917559 cites W2041430827 @default.
• W2067917559 cites W2051737824 @default.
• W2067917559 cites W2059094067 @default.
• W2067917559 cites W2080073156 @default.
• W2067917559 cites W2081515150 @default.
• W2067917559 cites W2087806279 @default.
• W2067917559 cites W2089984491 @default.
• W2067917559 cites W2105183598 @default.
• W2067917559 cites W2151638043 @default.
• W2067917559 cites W2159544707 @default.
• W2067917559 cites W2168728301 @default.
• W2067917559 cites W2171250148 @default.
• W2067917559 cites W2171430296 @default.
• W2067917559 cites W2313758756 @default.
• W2067917559 cites W2314077734 @default.
• W2067917559 cites W2328937185 @default.
• W2067917559 cites W2332609884 @default.
• W2067917559 cites W2462530172 @default.
• W2067917559 doi "https://doi.org/10.1016/j.jct.2014.05.005" @default.
• W2067917559 hasPublicationYear "2014" @default.
• W2067917559 type Work @default.
• W2067917559 sameAs 2067917559 @default.
• W2067917559 citedByCount "12" @default.
• W2067917559 countsByYear W20679175592015 @default.
• W2067917559 countsByYear W20679175592016 @default.
• W2067917559 countsByYear W20679175592017 @default.
• W2067917559 countsByYear W20679175592018 @default.
• W2067917559 countsByYear W20679175592020 @default.
• W2067917559 countsByYear W20679175592021 @default.
• W2067917559 countsByYear W20679175592022 @default.
• W2067917559 crossrefType "journal-article" @default.
• W2067917559 hasAuthorship W2067917559A5009799955 @default.
• W2067917559 hasAuthorship W2067917559A5017577532 @default.
• W2067917559 hasAuthorship W2067917559A5084917640 @default.
• W2067917559 hasConcept C155574463 @default.
• W2067917559 hasConcept C178790620 @default.
• W2067917559 hasConcept C185592680 @default.
• W2067917559 hasConcept C43617362 @default.
• W2067917559 hasConceptScore W2067917559C155574463 @default.
• W2067917559 hasConceptScore W2067917559C178790620 @default.
• W2067917559 hasConceptScore W2067917559C185592680 @default.
• W2067917559 hasConceptScore W2067917559C43617362 @default.
• W2067917559 hasLocation W20679175591 @default.
• W2067917559 hasOpenAccess W2067917559 @default.
• W2067917559 hasPrimaryLocation W20679175591 @default.
• W2067917559 hasRelatedWork W2050108200 @default.
• W2067917559 hasRelatedWork W2088669026 @default.
• W2067917559 hasRelatedWork W2113085427 @default.
• W2067917559 hasRelatedWork W2168611614 @default.
• W2067917559 hasRelatedWork W2317289584 @default.
• W2067917559 hasRelatedWork W2320547070 @default.
• W2067917559 hasRelatedWork W2330424792 @default.
• W2067917559 hasRelatedWork W2346084788 @default.
• W2067917559 hasRelatedWork W2604890884 @default.
• W2067917559 hasRelatedWork W2952439925 @default.
• W2067917559 hasVolume "79" @default.
• W2067917559 isParatext "false" @default.
• W2067917559 isRetracted "false" @default.
• W2067917559 magId "2067917559" @default.
• W2067917559 workType "article" @default.