Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067921680> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2067921680 abstract "Bone mastocytosis is characterized radiographically in some patients by diffuse osteosclerosis and in others by demineralization. The reason for these apparently conflicting bone features is unknown. Bone remodeling and marrow mastocytosis infiltration were studied in nine cases of mastocytosis with bone marrow involvement. Six men, ranging from 42 to 78 years of age, and three women, 43, 55, and 73 years old, comprised the series. Two patients had severe and diffuse osteosclerosis. Seven had diffuse demineralization, with crushed vertebrae in four, suggesting common osteoporosis. In three of the seven, cutaneous mastocytosis was absent. Bone biopsies were undecalcified and stained with toluidine blue. In the seven patients with demineralization, the number of marrow mastocytes was increased (154 +/- 24 versus 2 +/- 0.5/mm2 in normal postmenopausal osteoporosis). Mastocyte nodules covering 1-9% of the marrow area were present in all seven patients. These patients showed a significant increase in remodeling; bone formation rate was increased, coupled with a decrease in mean wall thickness. Concomitantly, osteoclast surfaces were increased, with an increased amount of bone resorbed. The two patients with diffuse osteosclerosis had a markedly different histology; mast cell infiltration was dramatically increased (mastocyte count greater than 1000/mm2) with diffuse marrow fibrosis. Bone volume was increased as well, and most of the bone was woven with an intratrabecular mineralization defect. High bone remodeling and decreased osteoblast activity can explain bone loss in mastocytosis with demineralization. Mastocytosis with osteosclerosis is characterized by a more extensive marrow mast-cell infiltration and fibrosis." @default.
- W2067921680 created "2016-06-24" @default.
- W2067921680 creator A5040623674 @default.
- W2067921680 creator A5059876592 @default.
- W2067921680 creator A5061016130 @default.
- W2067921680 date "1992-06-01" @default.
- W2067921680 modified "2023-09-27" @default.
- W2067921680 title "Bone Mastocytosis A Report of Nine Cases With a Bone Histomorphometnc Study" @default.
- W2067921680 doi "https://doi.org/10.1097/00003086-199206000-00036" @default.
- W2067921680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1600667" @default.
- W2067921680 hasPublicationYear "1992" @default.
- W2067921680 type Work @default.
- W2067921680 sameAs 2067921680 @default.
- W2067921680 citedByCount "21" @default.
- W2067921680 countsByYear W20679216802012 @default.
- W2067921680 countsByYear W20679216802014 @default.
- W2067921680 countsByYear W20679216802016 @default.
- W2067921680 crossrefType "journal-article" @default.
- W2067921680 hasAuthorship W2067921680A5040623674 @default.
- W2067921680 hasAuthorship W2067921680A5059876592 @default.
- W2067921680 hasAuthorship W2067921680A5061016130 @default.
- W2067921680 hasConcept C126322002 @default.
- W2067921680 hasConcept C142724271 @default.
- W2067921680 hasConcept C170033053 @default.
- W2067921680 hasConcept C170493617 @default.
- W2067921680 hasConcept C2776033226 @default.
- W2067921680 hasConcept C2776541429 @default.
- W2067921680 hasConcept C2777479973 @default.
- W2067921680 hasConcept C2780007613 @default.
- W2067921680 hasConcept C2780581156 @default.
- W2067921680 hasConcept C71924100 @default.
- W2067921680 hasConceptScore W2067921680C126322002 @default.
- W2067921680 hasConceptScore W2067921680C142724271 @default.
- W2067921680 hasConceptScore W2067921680C170033053 @default.
- W2067921680 hasConceptScore W2067921680C170493617 @default.
- W2067921680 hasConceptScore W2067921680C2776033226 @default.
- W2067921680 hasConceptScore W2067921680C2776541429 @default.
- W2067921680 hasConceptScore W2067921680C2777479973 @default.
- W2067921680 hasConceptScore W2067921680C2780007613 @default.
- W2067921680 hasConceptScore W2067921680C2780581156 @default.
- W2067921680 hasConceptScore W2067921680C71924100 @default.
- W2067921680 hasLocation W20679216801 @default.
- W2067921680 hasLocation W20679216802 @default.
- W2067921680 hasOpenAccess W2067921680 @default.
- W2067921680 hasPrimaryLocation W20679216801 @default.
- W2067921680 hasRelatedWork W1626899694 @default.
- W2067921680 hasRelatedWork W184473900 @default.
- W2067921680 hasRelatedWork W1906353506 @default.
- W2067921680 hasRelatedWork W1971623604 @default.
- W2067921680 hasRelatedWork W2045006939 @default.
- W2067921680 hasRelatedWork W2392570122 @default.
- W2067921680 hasRelatedWork W2807270313 @default.
- W2067921680 hasRelatedWork W3163250772 @default.
- W2067921680 hasRelatedWork W3167415912 @default.
- W2067921680 hasRelatedWork W3216145407 @default.
- W2067921680 isParatext "false" @default.
- W2067921680 isRetracted "false" @default.
- W2067921680 magId "2067921680" @default.
- W2067921680 workType "article" @default.